The Rheumatoid Arthritis Risk Gene AIRE Is Induced by Cytokines in Fibroblast-Like Synoviocytes and Augments the Pro-inflammatory Response.
Arthritis, Rheumatoid
/ genetics
Cells, Cultured
Chemokine CXCL10
/ metabolism
Humans
Inflammation
/ immunology
Interferon-gamma
/ immunology
Interleukin-1beta
/ immunology
Membrane Glycoproteins
/ metabolism
Polymorphism, Single Nucleotide
/ genetics
RNA Interference
RNA, Small Interfering
/ genetics
Synovial Membrane
/ immunology
Synoviocytes
/ metabolism
Transcription Factors
/ genetics
Tumor Necrosis Factor-alpha
/ immunology
AIRE Protein
AIRE
cytokines
fibroblast-like synoviocytes
inflammation
interferon response genes
rheumatoid arthritis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
07
03
2019
accepted:
31
05
2019
entrez:
6
7
2019
pubmed:
6
7
2019
medline:
21
10
2020
Statut:
epublish
Résumé
The autoimmune regulator AIRE controls the negative selection of self-reactive T-cells as well as the induction of regulatory T-cells in the thymus by mastering the transcription and presentation of tissue restricted antigens (TRAs) in thymic cells. However, extrathymic AIRE expression of hitherto unknown clinical significance has also been reported. Genetic polymorphisms of
Identifiants
pubmed: 31275320
doi: 10.3389/fimmu.2019.01384
pmc: PMC6591464
doi:
Substances chimiques
CXCL10 protein, human
0
Chemokine CXCL10
0
IFNG protein, human
0
IL1B protein, human
0
Interleukin-1beta
0
Membrane Glycoproteins
0
PDPN protein, human
0
RNA, Small Interfering
0
Transcription Factors
0
Tumor Necrosis Factor-alpha
0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1384Références
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