Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis.
Amitriptyline
/ pharmacology
Animals
Biomarkers
Citrobacter rodentium
/ immunology
Colitis
/ etiology
Disease Models, Animal
Disease Resistance
/ immunology
Disease Susceptibility
Enterobacteriaceae Infections
/ immunology
Enzyme Activation
/ drug effects
Host-Pathogen Interactions
/ immunology
Intestinal Mucosa
/ immunology
Macrophages
/ immunology
Mice
Mice, Knockout
Sphingomyelin Phosphodiesterase
/ metabolism
T-Lymphocyte Subsets
/ metabolism
Citrobacter rodentium
Th1
Th17
acid sphingomyelinase
amitriptyline
colitis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
05
03
2019
accepted:
03
06
2019
entrez:
6
7
2019
pubmed:
6
7
2019
medline:
17
9
2020
Statut:
epublish
Résumé
Inflammatory diseases of the gastrointestinal tract are emerging as a global problem with increased evidence and prevalence in numerous countries. A dysregulated sphingolipid metabolism occurs in patients with ulcerative colitis and is discussed to contribute to its pathogenesis. In the present study, we determined the impact of acid sphingomyelinase (Asm), which catalyzes the hydrolysis of sphingomyelin to ceramide, on the course of
Identifiants
pubmed: 31275322
doi: 10.3389/fimmu.2019.01386
pmc: PMC6594205
doi:
Substances chimiques
Biomarkers
0
Amitriptyline
1806D8D52K
Sphingomyelin Phosphodiesterase
EC 3.1.4.12
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1386Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
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