Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3).

Adenocarcinoma of Lung / blood Adult Aged Biomarkers, Tumor / blood Carcinoma, Large Cell / blood Carcinoma, Squamous Cell / blood Case-Control Studies Female Follow-Up Studies Humans Inflammation / blood Kynurenine / blood Lung Neoplasms / blood Male Middle Aged Neopterin / blood Prognosis Prospective Studies Risk Factors Small Cell Lung Carcinoma / blood Tryptophan / blood
kynurenine lung cancer neopterin quinolinic acid tryptophan

Journal

International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124

Informations de publication

Date de publication:
01 05 2020
Historique:
received: 18 02 2019
revised: 21 05 2019
accepted: 14 06 2019
pmc-release: 05 01 2021
pubmed: 6 7 2019
medline: 1 7 2020
entrez: 6 7 2019
Statut: ppublish

Résumé

Cell-mediated immune suppression may play an important role in lung carcinogenesis. We investigated the associations for circulating levels of tryptophan, kynurenine, kynurenine:tryptophan ratio (KTR), quinolinic acid (QA) and neopterin as markers of immune regulation and inflammation with lung cancer risk in 5,364 smoking-matched case-control pairs from 20 prospective cohorts included in the international Lung Cancer Cohort Consortium. All biomarkers were quantified by mass spectrometry-based methods in serum/plasma samples collected on average 6 years before lung cancer diagnosis. Odds ratios (ORs) and 95% confidence intervals (CIs) for lung cancer associated with individual biomarkers were calculated using conditional logistic regression with adjustment for circulating cotinine. Compared to the lowest quintile, the highest quintiles of kynurenine, KTR, QA and neopterin were associated with a 20-30% higher risk, and tryptophan with a 15% lower risk of lung cancer (all p

Identifiants

DOI: 10.1002/ijc.32555 PMID: 31276202 PMC: PMC6960354
pubmed: 31276202
doi: 10.1002/ijc.32555
pmc: PMC6960354
mid: NIHMS1063418
doi:

Substances chimiques

Biomarkers, Tumor 0
Kynurenine 343-65-7
Neopterin 670-65-5
Tryptophan 8DUH1N11BX

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2394-2405

Subventions

Organisme : NCI NIH HHS
ID : UM1CA182934
Pays : United States
Organisme : NIH HHS
ID : HL26490
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600002C
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA087969
Pays : United States
Organisme : NCI NIH HHS
ID : U01CA202979
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA173640
Pays : United States
Organisme : NIH HHS
ID : HL043851
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA186107
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201500005C
Pays : United States
Organisme : NIH HHS
ID : CA047988
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA182913
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA202979
Pays : United States
Organisme : NIH HHS
ID : CA34944
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA155340
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA182876
Pays : United States
Organisme : NIH HHS
ID : CA097193
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL043851
Pays : United States
Organisme : NIH HHS
ID : HL080467
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA092447
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100046C
Pays : United States
Organisme : NCI NIH HHS
ID : UM1CA167552
Pays : United States
Organisme : NIDA NIH HHS
ID : HHSN271201600004I
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA182934
Pays : United States
Organisme : NCI NIH HHS
ID : P30CA016087
Pays : United States
Organisme : NCI NIH HHS
ID : UM1CA182876
Pays : United States
Organisme : NCI NIH HHS
ID : UM1CA182910
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600003C
Pays : United States
Organisme : NIDA NIH HHS
ID : HHSN271201600004C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600004C
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA182913
Pays : United States
Organisme : NIH HHS
ID : HL34595
Pays : United States
Organisme : NCI NIH HHS
ID : R01CA144034
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA047988
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600001C
Pays : United States
Organisme : NIH HHS
ID : CA40360
Pays : United States
Organisme : NIH HHS
ID : HL099355
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL080467
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA167552
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA182910
Pays : United States
Organisme : NHLBI NIH HHS
ID : RC1 HL099355
Pays : United States
Organisme : NIH HHS
ID : P30ES000260
Pays : United States

Informations de copyright

© 2019 UICC.

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Auteurs

Joyce Y Huang (JY)

Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA.
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.

Tricia L Larose (TL)

Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health & Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.

Hung N Luu (HN)

Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA.
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
ORCID: 0000-0002-2172-1849

Renwei Wang (R)

Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA.

Anouar Fanidi (A)

Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.

Karine Alcala (K)

Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.

Victoria L Stevens (VL)

Behavior and Epidemiology Research Group, American Cancer Society, Inc., Atlanta, GA.

Stephanie J Weinstein (SJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD.

Demetrius Albanes (D)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD.

Neil E Caporaso (NE)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD.

Mark P Purdue (MP)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD.
ORCID: 0000-0003-1177-3108

Regina G Ziegler (RG)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD.

Neal D Freedman (ND)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD.

Qing Lan (Q)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD.

Ross L Prentice (RL)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.

Mary Pettinger (M)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.

Cynthia A Thomson (CA)

Department of Health Promotion Science, Mel & Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ.

Qiuyin Cai (Q)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.

Jie Wu (J)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.

William J Blot (WJ)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.

Xiao-Ou Shu (XO)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.
ORCID: 0000-0002-0711-8314

Wei Zheng (W)

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.
ORCID: 0000-0003-1226-070X

Alan A Arslan (AA)

Department of Obstetrics and Gynecology, Population Health, Environmental Medicine and Perlmutter Cancer Center, New York University School of Medicine, New York, NY.

Anne Zeleniuch-Jacquotte (A)

Department of Population Health and Environmental Medicine and Perlmutter Cancer Centre, New York University School of Medicine, New York, NY.

Loïc Le Marchand (L)

Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI.

Lynn R Wilkens (LR)

Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI.

Christopher A Haiman (CA)

Department of Prevention, Keck School of Medicine, University of Southern California, Los Angeles, CA.

Xuehong Zhang (X)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
ORCID: 0000-0002-8260-8508

Meir J Stampfer (MJ)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.

Jiali Han (J)

Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN.

Graham G Giles (GG)

Cancer Epidemiology and Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.

Allison M Hodge (AM)

Cancer Epidemiology and Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.

Gianluca Severi (G)

Cancer Epidemiology and Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Italian Institute for Genomic Medicine (IIGM), Torino, Italy.
Centre de Recherche en Epidemiologie et Santé des Populations (CESP) UMR1018 Inserm, Facultés de Médicine Université Paris-Saclay, UPS, UVSQ, Gustave Roussy, Villejuif, France.

Mikael Johansson (M)

Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.

Kjell Grankvist (K)

Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden.

Arnulf Langhammer (A)

HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway.

Kristian Hveem (K)

K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health & Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway.

Yong-Bing Xiang (YB)

State Key Laboratory of Oncogene and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
ORCID: 0000-0002-3840-9915

Hong-Lan Li (HL)

Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Yu-Tang Gao (YT)

Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Kala Visvanathan (K)

George W. Comstock Center for Public Health Research and Prevention Health Monitoring Unit, Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.

Per M Ueland (PM)

Department of Clinical Science, University of Bergen, Bergen, Norway.
Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway.

Øivind Midttun (Ø)

Bevital AS, Bergen, Norway.

Arve Ulvi (A)

Bevital AS, Bergen, Norway.

Julie E Buring (JE)

Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

I-Min Lee (IM)

Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Howard D Sesso (HD)

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA.
Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

J Michael Gaziano (JM)

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA.
Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Boston VA Medical Center, Boston, MA.

Jonas Manjer (J)

Department of Surgery, Skåne University Hospital Malmö Lund University, Malmö, Sweden.

Caroline Relton (C)

MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.

Woon-Puay Koh (WP)

Health Services and Systems Research, Duke-NUS Medical School, Singapore.
Saw Swee Hock School of Public Health, National University of Singapore, Singapore.

Paul Brennan (P)

Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.

Mattias Johansson (M)

Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.

Jian-Min Yuan (JM)

Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA.
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
ORCID: 0000-0002-4620-3108

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Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs du thorax › Adénocarcinome pulmonaire › Circulating markers of cellular immune...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Circulating markers of cellular immune...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Circulating markers of cellular immune...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Circulating markers of cellular immune...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Carcinome à grandes cellules › Circulating markers of cellular immune...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs épidermoïdes › Carcinome épidermoïde › Circulating markers of cellular immune...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Circulating markers of cellular immune...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études de suivi › Circulating markers of cellular immune...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Circulating markers of cellular immune...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Circulating markers of cellular immune...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Cynurénine › Circulating markers of cellular immune...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Circulating markers of cellular immune...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Circulating markers of cellular immune...
questionsmedicales.fr › Enzymes et coenzymes › Coenzymes › Bioptérine › Néoptérine › Circulating markers of cellular immune...
questionsmedicales.fr › Diagnostic › Pronostic › Circulating markers of cellular immune...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Circulating markers of cellular immune...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Circulating markers of cellular immune...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire à petites cellules › Circulating markers of cellular immune...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Tryptophane › Circulating markers of cellular immune...