Cocaine treatment before pregnancy differentially affects the anxiety and brain glucose metabolism of lactating rats if performed during adulthood or adolescence.
Age Factors
Animals
Anxiety
/ metabolism
Anxiety Disorders
/ metabolism
Brain
/ metabolism
Cocaine
/ metabolism
Cocaine-Related Disorders
/ metabolism
Dopamine Uptake Inhibitors
/ pharmacology
Female
Glucose
/ metabolism
Lactation
/ drug effects
Maternal Behavior
/ drug effects
Maze Learning
/ drug effects
Postpartum Period
/ drug effects
Prefrontal Cortex
/ drug effects
Pregnancy
Rats
Adolescence
Anxiety-like behavior
Basal glucose metabolism
Cocaine
Motherhood
Postpartum period
Journal
Behavioural brain research
ISSN: 1872-7549
Titre abrégé: Behav Brain Res
Pays: Netherlands
ID NLM: 8004872
Informations de publication
Date de publication:
17 10 2019
17 10 2019
Historique:
received:
13
03
2019
revised:
27
06
2019
accepted:
01
07
2019
pubmed:
6
7
2019
medline:
20
8
2020
entrez:
6
7
2019
Statut:
ppublish
Résumé
Cocaine exposure disrupts the maternal behavior of lactating rats, yet it is less known whether it alters the affective changes that accompany motherhood. As the long-term action of cocaine on anxiety varies according to the developmental stage of the individuals, this study aimed to compare the effect of a chronic treatment with cocaine to adult and adolescent non-pregnant females on their anxiety-like behavior and basal brain metabolic activity during lactation. Thus, adult and adolescent virgin rats were exposed to cocaine (0.0 or 15.0 mg/kg ip) during 10 days and were mated four days later. Anxiety behavior was evaluated on postpartum days 3-4 in the elevated plus maze test, and the basal brain glucose metabolism was determined on postpartum days 7-9 by means of [
Identifiants
pubmed: 31276701
pii: S0166-4328(19)30402-4
doi: 10.1016/j.bbr.2019.112070
pii:
doi:
Substances chimiques
Dopamine Uptake Inhibitors
0
Cocaine
I5Y540LHVR
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112070Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.