Carboplatin Enhances the Activity of Human Transient Receptor Potential Ankyrin 1 through the Cyclic AMP-Protein Kinase A-A-Kinase Anchoring Protein (AKAP) Pathways.
AKAP
CIPN
PKA
TRPA1
cAMP
carboplatin
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
03 Jul 2019
03 Jul 2019
Historique:
received:
14
06
2019
revised:
01
07
2019
accepted:
02
07
2019
entrez:
7
7
2019
pubmed:
7
7
2019
medline:
21
12
2019
Statut:
epublish
Résumé
Carboplatin, an anticancer drug, often causes chemotherapy-induced peripheral neuropathy (PN). Transient receptor potential ankyrin 1 (TRPA1), a non-selective cation channel, is a polymodal nociceptor expressed in sensory neurons. TRPA1 is not only involved in pain transmission, but also in allodynia or hyperalgesia development. However, the effects of TRPA1 on carboplatin-induced PN is unclear. We revealed that carboplatin induced mechanical allodynia and cold hyperalgesia, and the pains observed in carboplatin-induced PN models were significantly suppressed by the TRPA1 antagonist HC-030031 without a change in the level of TRPA1 protein. In cells expressing human TRPA, carboplatin had no effects on changes in intracellular Ca
Identifiants
pubmed: 31277262
pii: ijms20133271
doi: 10.3390/ijms20133271
pmc: PMC6651390
pii:
doi:
Substances chimiques
A Kinase Anchor Proteins
0
TRPA1 Cation Channel
0
Carboplatin
BG3F62OND5
Cyclic AMP
E0399OZS9N
Cyclic AMP-Dependent Protein Kinases
EC 2.7.11.11
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 23790315
Organisme : Japan Society for the Promotion of Science
ID : 25860199
Organisme : Japan Society for the Promotion of Science
ID : 16K08568
Organisme : Japan Society for the Promotion of Science
ID : 15K10522
Organisme : Japan Society for the Promotion of Science
ID : 15Ｋ08215
Organisme : Japan Society for the Promotion of Science
ID : 18K08858
Organisme : The Nakatomi Foundation
ID : none
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