Animal Models of Psychosis in Alzheimer Disease.
Alzheimer disease
Psychosis
animal model
dementia
mouse
preclinical
Journal
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
ISSN: 1545-7214
Titre abrégé: Am J Geriatr Psychiatry
Pays: England
ID NLM: 9309609
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
19
02
2019
revised:
29
04
2019
accepted:
13
05
2019
pubmed:
7
7
2019
medline:
5
1
2021
entrez:
7
7
2019
Statut:
ppublish
Résumé
Psychosis in Alzheimer Disease (AD) represents a distinct clinicopathologic variant associated with increased cognitive and functional morbidity and an accelerated disease course. To date, extant treatments offer modest benefits with significant risks. The development of new pharmacologic treatments for psychosis in AD would be facilitated by validated preclinical models with which to test candidate interventions. The current review provides a brief summary of the process of validating animal models of human disease together with a critical analysis of the challenges posed in attempting to apply those standards to AD-related behavioral models. An overview of phenotypic analogues of human cognitive and behavioral impairments, with an emphasis on those relevant to psychosis, in AD-related mouse models is provided, followed by an update on recent progress in efforts to translate findings in the pathophysiology of psychotic AD into novel models. Finally, some future directions are suggested to expand the catalogue of psychosis-relevant phenotypes that may provide a sturdier framework for model development and targets for preclinical treatment outcomes.
Identifiants
pubmed: 31278012
pii: S1064-7481(19)30364-1
doi: 10.1016/j.jagp.2019.05.009
pmc: PMC6858948
mid: NIHMS1533520
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-19Subventions
Organisme : NIA NIH HHS
ID : RF1 AG055974
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005133
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG027224
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH116046
Pays : United States
Organisme : BLRD VA
ID : I01 BX000452
Pays : United States
Informations de copyright
Copyright © 2019 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.
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