Fermented rice peptides attenuate scopolamine-induced memory impairment in mice by regulating neurotrophic signaling pathways in the hippocampus.

Acetylcholinesterase / metabolism Animals Brain-Derived Neurotrophic Factor / metabolism Cognitive Dysfunction / metabolism Cyclic AMP Response Element-Binding Protein / metabolism Extracellular Signal-Regulated MAP Kinases / metabolism Fermented Foods Hippocampus / drug effects Hydrogen Peroxide / metabolism Memory / drug effects Memory Disorders / chemically induced Mice Nerve Growth Factors Oryza / metabolism Peptides / pharmacology Phosphorylation Scopolamine / metabolism Signal Transduction / drug effects Temporal Lobe / metabolism
Acetylcholine Brain-derived neurotrophic factor Cognitive impairment Fermented rice Peptides

Journal

Brain research
ISSN: 1872-6240
Titre abrégé: Brain Res
Pays: Netherlands
ID NLM: 0045503

Informations de publication

Date de publication:
01 10 2019
Historique:
received: 28 04 2019
revised: 22 06 2019
accepted: 02 07 2019
pubmed: 7 7 2019
medline: 25 9 2020
entrez: 7 7 2019
Statut: ppublish

Résumé

This study investigated the preventive effects of fermented rice peptides (FRPs) against scopolamine-induced memory impairment in mice and their potential mechanisms. Mice were pretreated with FRPs (25 and 100 mg/kg body weight) via intraperitoneal injection for 7 days, followed by intraperitoneal injection of scopolamine. FRP pretreatment suppressed scopolamine-induced cognitive impairment in passive-avoidance test and significantly upregulated levels of brain-derived neurotrophic factor (BDNF) and induced the phosphorylation of cAMP response element binding (CREB) protein and extracellular signal-regulated kinase (ERK) in the hippocampus of scopolamine-treated mice. Additionally, scopolamine-treated mice showed significantly decreased acetylcholine levels and increased acetylcholine-esterase activity in the hippocampus as compared with controls; however, these changes were suppressed by FRP pretreatment. Among the fractions separated by size-exclusion chromatography, the non-glycosylated peptide fraction of FRP suppressed H

Identifiants

DOI: 10.1016/j.brainres.2019.146322 PMID: 31278934
pubmed: 31278934
pii: S0006-8993(19)30368-3
doi: 10.1016/j.brainres.2019.146322
pii:
doi:

Substances chimiques

Bdnf protein, mouse 0
Brain-Derived Neurotrophic Factor 0
Creb1 protein, mouse 0
Cyclic AMP Response Element-Binding Protein 0
Nerve Growth Factors 0
Peptides 0
Hydrogen Peroxide BBX060AN9V
Scopolamine DL48G20X8X
Extracellular Signal-Regulated MAP Kinases EC 2.7.11.24
Acetylcholinesterase EC 3.1.1.7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

146322

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Henry M Corpuz (HM)

Department of Bioscience and Food Production Science, Interdisciplinary Graduate School of Science and Technology, Shinshu University, 8304 Minamiminowa, Kamiina, Nagano 399-4598, Japan; Rice Chemistry and Food Science Division, Philippine Rice Research Institute, Maligaya, Science City of Muñoz, Nueva Ecija 3119, Philippines.

Hiroshi Fujii (H)

Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, 8304 Minamiminowa, Kamiina, Nagano 399-4598, Japan.

Soichiro Nakamura (S)

Department of Bioscience and Food Production Science, Interdisciplinary Graduate School of Science and Technology, Shinshu University, 8304 Minamiminowa, Kamiina, Nagano 399-4598, Japan.

Shigeru Katayama (S)

Department of Bioscience and Food Production Science, Interdisciplinary Graduate School of Science and Technology, Shinshu University, 8304 Minamiminowa, Kamiina, Nagano 399-4598, Japan; Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, 8304 Minamiminowa, Kamiina, Nagano 399-4598, Japan. Electronic address: skata@shinshu-u.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › Fermented rice peptides attenuate...
questionsmedicales.fr › Eucaryotes › Animaux › Fermented rice peptides attenuate...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Facteur neurotrophique dérivé du cerveau › Fermented rice peptides attenuate...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Fermented rice peptides attenuate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Protéine de liaison à l'élément de réponse à l'AMP cyclique › Fermented rice peptides attenuate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › Extracellular Signal-Regulated MAP Kinases › Fermented rice peptides attenuate...
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