Di(2-ethylhexyl) phthalate-induced toxicity and peroxisome proliferator-activated receptor alpha: a review.

Animals Diethylhexyl Phthalate / toxicity Environmental Pollutants / toxicity Haplorhini Humans Mice PPAR alpha / genetics Plasticizers / toxicity Rats
Carcinogenesis Developmental toxicity Di(2-ethylhexyl) phthalate Reproductive toxicity Science policy

Journal

Environmental health and preventive medicine
ISSN: 1347-4715
Titre abrégé: Environ Health Prev Med
Pays: Japan
ID NLM: 9609642

Informations de publication

Date de publication:
06 Jul 2019
Historique:
received: 26 03 2019
accepted: 28 06 2019
entrez: 8 7 2019
pubmed: 8 7 2019
medline: 2 11 2019
Statut: epublish

Résumé

The plasticizer di(2-ethylhexyl) phthalate (DEHP) has been widely used in the manufacture of polyvinyl chloride-containing products such as medical and consumer goods. Humans can easily be exposed to it because DEHP is ubiquitous in the environment. Recent research on the adverse effects of DEHP has focused on reproductive and developmental toxicity in rodents and/or humans. DEHP is a representative of the peroxisome proliferators. Therefore, peroxisome proliferator-activated receptor alpha (PPARα)-dependent pathways are the expected mode of action of several kinds of DEHP-induced toxicities. In this review, we summarize DEHP kinetics and its mechanisms of carcinogenicity and reproductive and developmental toxicity in relation to PPARα. Additionally, we give an overview of the impacts of science policy on exposure sources.

Identifiants

DOI: 10.1186/s12199-019-0802-z PMID: 31279339 PMC: PMC6612219
pubmed: 31279339
doi: 10.1186/s12199-019-0802-z
pii: 10.1186/s12199-019-0802-z
pmc: PMC6612219
doi:

Substances chimiques

Environmental Pollutants 0
PPAR alpha 0
Plasticizers 0
Diethylhexyl Phthalate C42K0PH13C

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

47

Subventions

Organisme : Japan Society for the Promotion of Science
ID : B. 14370121, B. 17390169
Organisme : Japan Society for the Promotion of Science
ID : C.25460808
Organisme : Health and Labor Sciences Research Grants from the Ministry of Health Labour and Welfare, Japan
ID : 200939055A
Organisme : Grants-in-Aid from Food Safety Commission, Japan
ID : No. 1002

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Auteurs

Yuki Ito (Y)

Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467-8601, Japan. yukey@med.nagoya-cu.ac.jp.
ORCID: 0000-0003-1617-1595

Michihiro Kamijima (M)

Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467-8601, Japan.

Tamie Nakajima (T)

College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi, 487-8501, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Di(2-ethylhexyl) phthalate-induced toxicity...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Acides phtaliques › Phtalate de bis[2-éthylhexyle] › Di(2-ethylhexyl) phthalate-induced toxicity...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Di(2-ethylhexyl) phthalate-induced toxicity...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Di(2-ethylhexyl) phthalate-induced toxicity...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Di(2-ethylhexyl) phthalate-induced toxicity...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Di(2-ethylhexyl) phthalate-induced toxicity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur PPAR alpha › Di(2-ethylhexyl) phthalate-induced toxicity...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Plastifiants › Di(2-ethylhexyl) phthalate-induced toxicity...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Di(2-ethylhexyl) phthalate-induced toxicity...