L-Alpha-glycerylphosphorylcholine can be cytoprotective or cytotoxic in neonatal rat cardiac myocytes: a double-edged sword phenomenon.
L-Alpha-glycerylphosphorylcholine
Mitochondrial dysfunction
Neonatal rat cardiac myocytes
Oxidative stress
Journal
Molecular and cellular biochemistry
ISSN: 1573-4919
Titre abrégé: Mol Cell Biochem
Pays: Netherlands
ID NLM: 0364456
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
17
10
2018
accepted:
25
06
2019
pubmed:
8
7
2019
medline:
14
1
2020
entrez:
8
7
2019
Statut:
ppublish
Résumé
L-Alpha-glycerylphosphorylcholine (GPC) is a widely used food supplement. GPC has been shown to exert beneficial effects in several organs; however, the cardiac effects of GPC have yet to be investigated. The aim of the present study was therefore to map out the effects of GPC on cardiac myocytes, with or without ischemia-reperfusion insult. Neonatal rat cardiac myocytes were treated with GPC at 1, 10, 80, and 100 µM concentrations for 15 min, 3 h, or 24 h, respectively. Cell viability by calcein assay and the degree of oxidative stress by DHE (superoxide level) and H
Identifiants
pubmed: 31280435
doi: 10.1007/s11010-019-03580-1
pii: 10.1007/s11010-019-03580-1
pmc: PMC6745025
doi:
Substances chimiques
Glycerylphosphorylcholine
60M22SGW66
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
195-203Subventions
Organisme : VEGA
ID : SR no. 2/0061/16
Organisme : GINOP
ID : 2.3.2-15-2016-00040
Organisme : OTKA
ID : PD 106001
Organisme : Development and Innovation Office of Hungary
ID : NKFIH
Organisme : Development and Innovation Office of Hungary
ID : NVKP-16-1-2016-0017
Organisme : Development and Innovation Office of Hungary
ID : NKFIH K 120232
Organisme : Hungarian Academy of Sciences
ID : János Bolyai Fellowship (2012-15)
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