Identification of Salivary Microbiota and Its Association With Host Inflammatory Mediators in Periodontitis.
Adult
Aged
Aged, 80 and over
Bacteria
/ classification
Biomarkers
Chronic Periodontitis
/ immunology
Cytokines
/ metabolism
Dysbiosis
Female
Host Microbial Interactions
/ immunology
Humans
Inflammation Mediators
Male
Microbiota
Middle Aged
Periodontium
/ microbiology
RNA, Ribosomal, 16S
/ genetics
Saliva
/ immunology
Young Adult
16S rRNA sequencing
cytokines
inflammatory mediators
microbiome
microbiota
periodontitis
saliva
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2019
2019
Historique:
received:
18
04
2019
accepted:
05
06
2019
entrez:
9
7
2019
pubmed:
10
7
2019
medline:
19
2
2020
Statut:
epublish
Résumé
Periodontitis is a microbial-induced chronic inflammatory disease, which may not only result in tooth loss, but can also contribute to the development of various systemic diseases. The transition from healthy to diseased periodontium depends on microbial dysbiosis and impaired host immune response. Although periodontitis is a common disease as well as associated with various systemic inflammatory conditions, the taxonomic profiling of the salivary microbiota in periodontitis and its association with host immune and inflammatory mediators has not been reported. Therefore, the aim of this study was to identify key pathogens and their potential interaction with the host's inflammatory mediators in saliva samples for periodontitis risk assessment. The microbial 16S rRNA gene sequencing and the levels of inflammatory mediators were performed in saliva samples from patients with chronic periodontitis and periodontally healthy control subjects. The salivary microbial community composition differed significantly between patients with chronic periodontitis and healthy controls. Our analyses identified a number of microbes, including bacteria assigned to
Identifiants
pubmed: 31281801
doi: 10.3389/fcimb.2019.00216
pmc: PMC6598052
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
Inflammation Mediators
0
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
216Références
J Dent Res. 2014 Nov;93(11):1045-53
pubmed: 25261053
Front Cell Infect Microbiol. 2016 Dec 22;6:196
pubmed: 28066728
ISME J. 2013 May;7(5):1016-25
pubmed: 23303375
J Dent Res. 2014 Sep;93(9):846-58
pubmed: 25074492
J Periodontol. 2009 Sep;80(9):1421-32
pubmed: 19722792
Sci Rep. 2018 Jan 24;8(1):1484
pubmed: 29367728
Odontology. 2012 Jul;100(2):215-21
pubmed: 21932007
Front Microbiol. 2017 Nov 01;8:2144
pubmed: 29163429
Oral Microbiol Immunol. 2004 Dec;19(6):379-85
pubmed: 15491463
Expert Rev Mol Med. 2013 Aug 05;15:e7
pubmed: 23915822
Sci Rep. 2017 Jun 16;7(1):3703
pubmed: 28623321
J Periodontol. 2018 May;89(5):531-539
pubmed: 29520798
ISME J. 2014 Sep;8(9):1879-91
pubmed: 24671083
J Periodontal Res. 2013 Feb;48(1):44-51
pubmed: 22812409
Nat Rev Endocrinol. 2011 Jun 28;7(12):738-48
pubmed: 21709707
BMC Bioinformatics. 2011 Jun 22;12:253
pubmed: 21693065
J Clin Periodontol. 1998 Feb;25(2):134-44
pubmed: 9495612
Nat Methods. 2016 Jul;13(7):581-3
pubmed: 27214047
J Clin Microbiol. 2013 Sep;51(9):2850-61
pubmed: 23784124
PLoS One. 2010 Apr 06;5(4):e10029
pubmed: 20386591
PLoS One. 2013 Apr 22;8(4):e61217
pubmed: 23630581
Front Microbiol. 2015 Feb 24;6:119
pubmed: 25814980
Front Cell Infect Microbiol. 2018 May 01;8:124
pubmed: 29765908
ISME J. 2011 Oct;5(10):1571-9
pubmed: 21472016
Genome Biol. 2014;15(12):550
pubmed: 25516281
J Periodontol. 2012 Nov;83(11):1337-42
pubmed: 22324489
J Clin Periodontol. 2016 Jun;43(6):492-502
pubmed: 26926312
Bull Acad Natl Med. 1986 Jan;170(1):79-91
pubmed: 3527355
J Dent Res. 2003 May;82(5):338-44
pubmed: 12709498
Nat Rev Dis Primers. 2017 Sep 14;3:17069
pubmed: 28905941
Oral Dis. 2019 May;25(4):982-995
pubmed: 29969843
J Clin Periodontol. 2012 May;39(5):425-33
pubmed: 22417294
J Periodontal Res. 2003 Aug;38(4):436-9
pubmed: 12828663
PLoS One. 2013 Jun 06;8(6):e65520
pubmed: 23762384
J Periodontal Res. 2010 Jun;45(3):389-95
pubmed: 20337892
Appl Environ Microbiol. 2007 Aug;73(16):5261-7
pubmed: 17586664
Periodontol 2000. 2012 Oct;60(1):15-39
pubmed: 22909104
J Clin Invest. 2004 Feb;113(3):379-89
pubmed: 14755335
J Dent Res. 2016 Jun;95(6):711-8
pubmed: 26936213
Sci Rep. 2015 Dec 21;5:18475
pubmed: 26686060
Dis Markers. 2011;30(6):299-305
pubmed: 21725158
Sci Rep. 2016 Feb 24;6:22164
pubmed: 26907866
PLoS One. 2018 Nov 26;13(11):e0200900
pubmed: 30475813
J Clin Periodontol. 2014 Feb;41(2):104-12
pubmed: 24303924
J Dent Res. 2015 Oct;94(10):1425-31
pubmed: 26198391
Nat Rev Microbiol. 2010 Jul;8(7):481-90
pubmed: 20514045
J Periodontol. 2014 Jun;85(6):819-28
pubmed: 24144271
PLoS One. 2017 Aug 11;12(8):e0182992
pubmed: 28800622
J Periodontol. 2015 May;86(5):611-22
pubmed: 25688694
Trends Immunol. 2014 Jan;35(1):3-11
pubmed: 24269668
J Clin Periodontol. 2013 Feb;40(2):140-7
pubmed: 23174014
PLoS Comput Biol. 2017 Nov 3;13(11):e1005752
pubmed: 29099853
PLoS One. 2013;8(3):e58487
pubmed: 23520516
Nat Rev Immunol. 2015 Jan;15(1):30-44
pubmed: 25534621
Front Cell Infect Microbiol. 2015 Oct 01;5:69
pubmed: 26484315
Clin Microbiol Rev. 2013 Oct;26(4):781-91
pubmed: 24092855
Front Cell Infect Microbiol. 2018 Aug 03;8:267
pubmed: 30123780
Periodontol 2000. 1997 Jun;14:9-11
pubmed: 9567963
J Clin Periodontol. 2011 Mar;38 Suppl 11:85-105
pubmed: 21323706
ISME J. 2012 Jun;6(6):1176-85
pubmed: 22170420
Sci Rep. 2015 Mar 12;5:9053
pubmed: 25761675
J Dent Res. 2010 Sep;89(9):879-902
pubmed: 20639510
Acta Odontol Scand. 2015;73(8):563-8
pubmed: 25891035
J Bacteriol. 2010 Oct;192(19):5002-17
pubmed: 20656903
PLoS One. 2012;7(6):e37919
pubmed: 22675498
PLoS One. 2017 Apr 3;12(4):e0174782
pubmed: 28369125
Nat Rev Cardiol. 2010 Sep;7(9):479-80
pubmed: 20725103
Nat Methods. 2010 May;7(5):335-6
pubmed: 20383131
NPJ Biofilms Microbiomes. 2017 Oct 2;3:23
pubmed: 28979798
ISME J. 2018 May;12(5):1210-1224
pubmed: 29339824