Isolation, Synthesis And Structure Determination Of Cannabidiol Derivatives And Their Cytotoxic Activities.

Antineoplastic Agents, Phytogenic / chemistry Cannabidiol / chemistry Cannabis / chemistry Cell Line, Tumor Density Functional Theory Drug Screening Assays, Antitumor Humans Magnetic Resonance Spectroscopy Molecular Structure
Cannabidiol Cannabinoids Cannabis sativa L. Cytotoxic activities Divergent synthesis

Journal

Natural product research
ISSN: 1478-6427
Titre abrégé: Nat Prod Res
Pays: England
ID NLM: 101167924

Informations de publication

Date de publication:
Feb 2021
Historique:
pubmed: 10 7 2019
medline: 10 3 2021
entrez: 9 7 2019
Statut: ppublish

Résumé

In a continuing effort to explore the structural diversity and pharmacological activities of natural products based scaffolds, herein, we report the isolation, synthesis, and structure determination of cannabidiol and its derivatives along with their cytotoxic activities. Treatment of cannabidiol (

Identifiants

DOI: 10.1080/14786419.2019.1638381 PMID: 31282748
pubmed: 31282748
doi: 10.1080/14786419.2019.1638381
doi:

Substances chimiques

Antineoplastic Agents, Phytogenic 0
Cannabidiol 19GBJ60SN5

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

471-480

Auteurs

Yedukondalu Nalli (Y)

Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K, 180001, India.
Academy of Scientific and Innovative Research, New Delhi, India.

Suraya Jan (S)

Academy of Scientific and Innovative Research, New Delhi, India.
Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, Sanatnagar Srinagar, 180001, India and 190005.

Gianluigi Lauro (G)

Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, Fisciano, 84084, Italy.

Javeed Ur Rasool (J)

Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K, 180001, India.
Academy of Scientific and Innovative Research, New Delhi, India.

Waseem I Lone (WI)

Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K, 180001, India.
Academy of Scientific and Innovative Research, New Delhi, India.

Aminur R Sarkar (AR)

Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K, 180001, India.

Junaid Banday (J)

Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K, 180001, India.

Giuseppe Bifulco (G)

Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, Fisciano, 84084, Italy.

Hartmut Laatsch (H)

Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstr. 2, Göttingen, D-37077, Germany.

Sajad H Syed (SH)

Academy of Scientific and Innovative Research, New Delhi, India.
Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, Sanatnagar Srinagar, 180001, India and 190005.
ORCID: 0000-0002-0382-4000

Asif Ali (A)

Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K, 180001, India.
Academy of Scientific and Innovative Research, New Delhi, India.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antinéoplasiques d'origine végétale › Isolation, Synthesis And Structure...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Cannabinoïdes › Cannabidiol › Isolation, Synthesis And Structure...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Rosanae › Rosales › Cannabaceae › Cannabis › Isolation, Synthesis And Structure...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Isolation, Synthesis And Structure...
questionsmedicales.fr › Disciplines des sciences naturelles › Physique › Physique nucléaire › Théorie quantique › Théorie de la fonctionnelle de la densité › Isolation, Synthesis And Structure...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de criblage d'agents antitumoraux › Isolation, Synthesis And Structure...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Isolation, Synthesis And Structure...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Isolation, Synthesis And Structure...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Isolation, Synthesis And Structure...