Complement component C5a induces aberrant epigenetic modifications in renal tubular epithelial cells accelerating senescence by Wnt4/βcatenin signaling after ischemia/reperfusion injury.

Acute Kidney Injury / etiology Cells, Cultured Cellular Senescence Complement C5a / physiology Cyclin-Dependent Kinase 6 / metabolism Cytochrome P-450 CYP1B1 / metabolism DNA Methylation Epigenesis, Genetic Epithelial Cells / metabolism Humans Kidney Tubules / metabolism Reperfusion Injury / etiology Transcription Factors / metabolism Wnt Signaling Pathway
DNA methylation acute kidney injury complement cascade renal Inflammaging

Journal

Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617

Informations de publication

Date de publication:
08 07 2019
Historique:
received: 08 03 2019
accepted: 24 06 2019
pubmed: 10 7 2019
medline: 22 7 2020
entrez: 9 7 2019
Statut: ppublish

Résumé

Epigenetic mechanisms, such as DNA methylation, affect tubular maladaptive response after Acute Kidney Injury (AKI) and accelerate renal aging. Upon ischemia/reperfusion (I/R) injury, Complement activation leads to C5a release that mediates damage; however, little is known about the effect of C5a-C5a Receptor (C5aR) interaction in Renal Tubular Epithelial Cells (RTEC).Through a whole-genome DNA methylation analysis in cultured RTEC, we found that C5a induced aberrant methylation, particularly in regions involved in cell cycle control, DNA damage and Wnt signaling. The most represented genes were

Identifiants

DOI: 10.18632/aging.102059 PMID: 31284268 PMC: PMC6660044
pubmed: 31284268
doi: 10.18632/aging.102059
pii: 102059
pmc: PMC6660044
doi:

Substances chimiques

BCL9 protein, human 0
Transcription Factors 0
Complement C5a 80295-54-1
CYP1B1 protein, human EC 1.14.14.1
Cytochrome P-450 CYP1B1 EC 1.14.14.1
CDK6 protein, human EC 2.7.11.22
Cyclin-Dependent Kinase 6 EC 2.7.11.22

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4382-4406

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK119431
Pays : United States

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Auteurs

Giuseppe Castellano (G)

Nephrology, Dialysis and Transplantation Unit, University of Bari "Aldo Moro", Bari, Italy.

Rossana Franzin (R)

Nephrology, Dialysis and Transplantation Unit, University of Bari "Aldo Moro", Bari, Italy.

Fabio Sallustio (F)

Nephrology, Dialysis and Transplantation Unit, University of Bari "Aldo Moro", Bari, Italy.
Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari "Aldo Moro", Bari, Italy.

Alessandra Stasi (A)

Nephrology, Dialysis and Transplantation Unit, University of Bari "Aldo Moro", Bari, Italy.

Barbara Banelli (B)

IRCCS Ospedale Policlinico San Martino, Genova, Italy.

Massimo Romani (M)

IRCCS Ospedale Policlinico San Martino, Genova, Italy.

Giuseppe De Palma (G)

Nephrology, Dialysis and Transplantation Unit, University of Bari "Aldo Moro", Bari, Italy.

Giuseppe Lucarelli (G)

Urology, Andrology and Renal Transplantation Unit, University of Bari, Bari, Italy.

Chiara Divella (C)

Nephrology, Dialysis and Transplantation Unit, University of Bari "Aldo Moro", Bari, Italy.

Michele Battaglia (M)

Urology, Andrology and Renal Transplantation Unit, University of Bari, Bari, Italy.

Antonio Crovace (A)

Veterinary Surgery Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.

Francesco Staffieri (F)

Veterinary Surgery Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.

Giuseppe Grandaliano (G)

Nephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.

Giovanni Stallone (G)

Nephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.

Pasquale Ditonno (P)

Urology, Andrology and Renal Transplantation Unit, University of Bari, Bari, Italy.

Paolo Cravedi (P)

Department of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Vincenzo Cantaluppi (V)

Nephrology and Kidney Transplantation Unit, Department of Translational Medicine, University of Eastern Piedmont "A. Avogadro" (UPO), Novara, Italy.

Loreto Gesualdo (L)

Nephrology, Dialysis and Transplantation Unit, University of Bari "Aldo Moro", Bari, Italy.

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Classifications MeSH

questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Insuffisance rénale › Atteinte rénale aigüe › Complement component C5a induces aberrant...
questionsmedicales.fr › Cellules › Cellules cultivées › Complement component C5a induces aberrant...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › Complement component C5a induces aberrant...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Immunoprotéines › Protéines du système du complément › Complément C5 › Complément C5a › Complement component C5a induces aberrant...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Proline-directed protein kinases › Kinases cyclines-dépendantes › Kinase-6 cycline-dépendante › Complement component C5a induces aberrant...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Famille-1 de cytochromes P450 › Cytochrome P-450 CYP1B1 › Complement component C5a induces aberrant...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Complement component C5a induces aberrant...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Complement component C5a induces aberrant...
questionsmedicales.fr › Cellules › Cellules épithéliales › Complement component C5a induces aberrant...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Complement component C5a induces aberrant...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Néphrons › Tubules rénaux › Complement component C5a induces aberrant...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Lésion d'ischémie-reperfusion › Complement component C5a induces aberrant...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Complement component C5a induces aberrant...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Voie de signalisation Wnt › Complement component C5a induces aberrant...