Evaluating the Anti-cancer Efficacy of a Synthetic Curcumin Analog on Human Melanoma Cells and Its Interaction with Standard Chemotherapeutics.
Antineoplastic Agents, Phytogenic
/ chemical synthesis
Apoptosis
/ drug effects
Cell Line, Tumor
Cell Survival
/ drug effects
Cisplatin
/ pharmacology
Curcumin
/ analogs & derivatives
Dose-Response Relationship, Drug
Drug Interactions
Humans
Melanoma
/ drug therapy
Mitochondria
/ drug effects
Molecular Structure
Oxidative Stress
/ drug effects
Paclitaxel
/ pharmacology
Tamoxifen
/ pharmacology
apoptosis
cisplatin
curcumin analog
drug–drug interaction
melanoma
oxidative stress
tamoxifen
taxol
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
06 Jul 2019
06 Jul 2019
Historique:
received:
18
06
2019
revised:
02
07
2019
accepted:
04
07
2019
entrez:
10
7
2019
pubmed:
10
7
2019
medline:
18
12
2019
Statut:
epublish
Résumé
Melanoma is the leading cause of skin-cancer related deaths in North America. Metastatic melanoma is difficult to treat and chemotherapies have limited success. Furthermore, chemotherapies lead to toxic side effects due to nonselective targeting of normal cells. Curcumin is a natural product of
Identifiants
pubmed: 31284561
pii: molecules24132483
doi: 10.3390/molecules24132483
pmc: PMC6651075
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Tamoxifen
094ZI81Y45
Curcumin
IT942ZTH98
Paclitaxel
P88XT4IS4D
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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