Candidalysin: discovery and function in Candida albicans infections.
Journal
Current opinion in microbiology
ISSN: 1879-0364
Titre abrégé: Curr Opin Microbiol
Pays: England
ID NLM: 9815056
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
23
04
2019
revised:
03
06
2019
accepted:
03
06
2019
pubmed:
10
7
2019
medline:
29
7
2020
entrez:
10
7
2019
Statut:
ppublish
Résumé
Candidalysin is a cytolytic peptide toxin secreted by the invasive form of the human pathogenic fungus, Candida albicans. Candidalysin is critical for mucosal and systemic infections and is a key driver of host cell activation, neutrophil recruitment and Type 17 immunity. Candidalysin is regarded as the first true classical virulence factor of C. albicans but also triggers protective immune responses. This review will discuss how candidalysin was discovered, the mechanisms by which this peptide toxin contributes to C. albicans infections, and how its discovery has advanced our understanding of fungal pathogenesis and disease.
Identifiants
pubmed: 31288097
pii: S1369-5274(18)30094-8
doi: 10.1016/j.mib.2019.06.002
pmc: PMC6687503
mid: EMS83881
pii:
doi:
Substances chimiques
ECE1 protein, Candida albicans
0
Fungal Proteins
0
Mycotoxins
0
Virulence Factors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100-109Subventions
Organisme : NIDCR NIH HHS
ID : R37 DE022550
Pays : United States
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N014677/1
Pays : United Kingdom
Organisme : Department of Health
ID : IS-BRC-1215-20006
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 214229
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_16048
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
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