Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium tuberculosis Is Counteracted by Mutations in the Metal Ion Transporter CorA.

Antitubercular Agents / pharmacology Cation Transport Proteins / genetics DNA Replication Homeostasis Magnesium / metabolism Mutation Mycobacterium tuberculosis / drug effects
CorA magnesium mycobacterium tuberculosis

Journal

mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231

Informations de publication

Date de publication:
09 07 2019
Historique:
entrez: 11 7 2019
pubmed: 11 7 2019
medline: 8 5 2020
Statut: epublish

Résumé

A defining characteristic of treating tuberculosis is the need for prolonged administration of multiple drugs. This may be due in part to subpopulations of slowly replicating or nonreplicating

Identifiants

DOI: 10.1128/mBio.01405-19 PMID: 31289182 PMC: PMC6747715
pubmed: 31289182
pii: mBio.01405-19
doi: 10.1128/mBio.01405-19
pmc: PMC6747715
pii:
doi:

Substances chimiques

Antitubercular Agents 0
Cation Transport Proteins 0
Magnesium I38ZP9992A

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2019 Lopez Quezada et al.

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Auteurs

Landys Lopez Quezada (L)

Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA.

Sandra Silve (S)

Evotec Infectious Diseases (Lyon), Marcy l'Etoile, France.

Mark Kelinske (M)

Agilent Technologies, Inc., Wilmington, Delaware, USA.

Amir Liba (A)

Agilent Technologies, Inc., Wilmington, Delaware, USA.

Constantino Diaz Gonzalez (C)

Evotec Research Informatics (Toulouse), Toulouse, France.

Martin Kotev (M)

Evotec Research Informatics (Toulouse), Toulouse, France.

Laurent Goullieux (L)

Evotec Infectious Diseases (Lyon), Marcy l'Etoile, France.

Stephanie Sans (S)

Evotec Infectious Diseases (Lyon), Marcy l'Etoile, France.

Christine Roubert (C)

Evotec Infectious Diseases (Lyon), Marcy l'Etoile, France.

Sophie Lagrange (S)

Evotec Infectious Diseases (Lyon), Marcy l'Etoile, France.

Eric Bacqué (E)

Evotec Infectious Diseases (Lyon), Marcy l'Etoile, France.

Cedric Couturier (C)

Evotec Infectious Diseases (Lyon), Marcy l'Etoile, France.

Alain Pellet (A)

Evotec Infectious Diseases (Lyon), Marcy l'Etoile, France.

Isabelle Blanc (I)

Evotec Infectious Diseases (Lyon), Marcy l'Etoile, France.

Marlène Ferron (M)

Evotec Infectious Diseases (Lyon), Marcy l'Etoile, France.

Fabrice Debu (F)

Evotec Infectious Diseases (Lyon), Marcy l'Etoile, France.

Kelin Li (K)

Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Jeffrey Aubé (J)

Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
ORCID: 0000-0003-1049-5767

Julia Roberts (J)

Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA.

David Little (D)

Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA.

Yan Ling (Y)

Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA.

Jun Zhang (J)

Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA.

Ben Gold (B)

Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA.

Carl Nathan (C)

Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA cnathan@med.cornell.edu.
ORCID: 0000-0002-7744-8896

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antituberculeux › Bactericidal Disruption of Magnesium...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs de cations › Bactericidal Disruption of Magnesium...
questionsmedicales.fr › Phénomènes génétiques › Réplication de l'ADN › Bactericidal Disruption of Magnesium...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Bactericidal Disruption of Magnesium...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Magnésium › Bactericidal Disruption of Magnesium...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Bactericidal Disruption of Magnesium...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Bactericidal Disruption of Magnesium...