Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome.
haploinsufficiency
Brugada syndrome
autonomic nervous system
conduction
Journal
American journal of physiology. Cell physiology
ISSN: 1522-1563
Titre abrégé: Am J Physiol Cell Physiol
Pays: United States
ID NLM: 100901225
Informations de publication
Date de publication:
01 09 2019
01 09 2019
Historique:
pubmed:
11
7
2019
medline:
2
4
2020
entrez:
11
7
2019
Statut:
ppublish
Résumé
A murine line haploinsufficient in the cardiac sodium channel has been used to model human Brugada syndrome: a disease causing sudden cardiac death due to lethal ventricular arrhythmias. We explored the effects of cholinergic tone on electrophysiological parameters in wild-type and genetically modified, heterozygous,
Identifiants
pubmed: 31291141
doi: 10.1152/ajpcell.00028.2019
pmc: PMC6766618
doi:
Substances chimiques
NAV1.5 Voltage-Gated Sodium Channel
0
Scn5a protein, mouse
0
Sodium Channels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
C576-C583Subventions
Organisme : British Heart Foundation
ID : RG/15/15/31742
Pays : United Kingdom
Organisme : Medical Research Council
Pays : United Kingdom
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