Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia.
Adenocarcinoma
/ genetics
Animals
Cell Line, Tumor
Cell Transformation, Neoplastic
/ genetics
Epithelial Cells
Gastric Mucosa
/ cytology
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Interleukin-6
/ metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Primary Cell Culture
/ methods
STAT3 Transcription Factor
/ metabolism
Signal Transduction
/ genetics
Stomach Neoplasms
/ genetics
Tissue Array Analysis
Trefoil Factor-1
/ genetics
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
10 07 2019
10 07 2019
Historique:
received:
20
12
2017
accepted:
12
06
2019
entrez:
12
7
2019
pubmed:
12
7
2019
medline:
23
10
2019
Statut:
epublish
Résumé
TFF1, a secreted protein, plays an essential role in keeping the integrity of gastric mucosa and its barrier function. Loss of TFF1 expression in the TFF1-knockout (KO) mouse leads to a pro-inflammatory phenotype with a cascade of gastric lesions that include low-grade dysplasia, high-grade dysplasia, and adenocarcinomas. In this study, we demonstrate nuclear localization of p-STAT
Identifiants
pubmed: 31292446
doi: 10.1038/s41467-019-11011-4
pii: 10.1038/s41467-019-11011-4
pmc: PMC6620282
doi:
Substances chimiques
IL6 protein, human
0
Interleukin-6
0
STAT3 Transcription Factor
0
STAT3 protein, human
0
Stat3 protein, mouse
0
TFF1 protein, human
0
Tff1 protein, mouse
0
Trefoil Factor-1
0
interleukin-6, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
3039Subventions
Organisme : NCI NIH HHS
ID : R01 CA077955
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK058404
Pays : United States
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R01CA93999
Pays : International
Organisme : NCI NIH HHS
ID : P01 CA116087
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA093999
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA240139
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA236733
Pays : United States
Organisme : BLRD VA
ID : IK6 BX003787
Pays : United States
Organisme : BLRD VA
ID : I01 BX001179
Pays : United States
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