[Tolerance of hypofractionated stereotactic radiotherapy for hepatic tumours].
Tolérance de l’irradiation stéréotaxique hypofractionnée des tumeurs hépatiques.
Aged
Aged, 80 and over
Antineoplastic Agents
/ therapeutic use
Carcinoma
/ radiotherapy
Carcinoma, Hepatocellular
/ radiotherapy
Cholangiocarcinoma
/ radiotherapy
Combined Modality Therapy
Disease-Free Survival
Embolization, Therapeutic
Female
Follow-Up Studies
France
/ epidemiology
Hemorrhage
/ etiology
Hepatectomy
Hepatic Artery
/ radiation effects
Humans
Liver Neoplasms
/ radiotherapy
Male
Middle Aged
Polyethylene
/ radiation effects
Polymers
/ radiation effects
Radiation Dose Hypofractionation
Radiation Injuries
/ epidemiology
Radiosurgery
/ adverse effects
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Intensity-Modulated
/ methods
Retrospective Studies
Stents
Artère hépatique
Haemorrhage
Hepatic
Hepatic artery
Hémorragie
Hépatique
Radiothérapie stéréotaxique
Stereotactic radiotherapy
Toxicity
Toxicités
Journal
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
ISSN: 1769-6658
Titre abrégé: Cancer Radiother
Pays: France
ID NLM: 9711272
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
20
09
2018
revised:
15
02
2019
accepted:
21
02
2019
pubmed:
14
7
2019
medline:
17
9
2019
entrez:
14
7
2019
Statut:
ppublish
Résumé
The purpose of the study was to evaluate the outcomes of stereotactic radiation therapy for primary and secondary liver tumours in Jean-Perrin cancer centre (Clermont-Ferrand, France) in terms of efficacy and safety. Between December 2013 and June 2016, 25 patients were included. Treatment was performed on a linear accelerator Novalis TX Median follow-up was 10.5 months. Treatment tolerance was good with few side effects grade 3 or above, no acute toxicity and only one late toxicity. We have highlighted that hepatic artery haemorrhage was associated with the presence of a biliary prosthesis in contact with the artery (P=0.006) and in the irradiation field. There was no correlation with the dose delivered to the artery and hepatic artery haemorrhage. Stereotactic radiation therapy for liver tumours allows a good local control with few secondary effects. Caution should be exercised when treating patients with biliary prostheses in the vicinity of the target volume because there is a risk of haemorrhage of the hepatic artery in contact with the prosthesis.
Identifiants
pubmed: 31300328
pii: S1278-3218(19)30139-8
doi: 10.1016/j.canrad.2019.02.004
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Polymers
0
Polyethylene
9002-88-4
Types de publication
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
385-394Informations de copyright
Copyright © 2019 Société française de radiothérapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.