Genome-wide CRISPR screens reveal genetic mediators of cereblon modulator toxicity in primary effusion lymphoma.

Adaptor Proteins, Signal Transducing / genetics CRISPR-Cas Systems Clustered Regularly Interspaced Short Palindromic Repeats Cullin Proteins / metabolism Drug Resistance, Neoplasm / genetics Endopeptidases / genetics Gene Knockdown Techniques Genome-Wide Association Study Humans Lenalidomide / adverse effects Lymphoma, Primary Effusion / drug therapy Models, Biological Thalidomide / analogs & derivatives Ubiquitin-Protein Ligases

Journal

Blood advances
ISSN: 2473-9537
Titre abrégé: Blood Adv
Pays: United States
ID NLM: 101698425

Informations de publication

Date de publication:
23 07 2019
Historique:
received: 15 01 2019
accepted: 17 05 2019
entrez: 14 7 2019
pubmed: 14 7 2019
medline: 8 7 2020
Statut: ppublish

Résumé

Genome-wide CRISPR/Cas9 screens represent a powerful approach to studying mechanisms of drug action and resistance. Cereblon modulating agents (CMs) have recently emerged as candidates for therapeutic intervention in primary effusion lymphoma (PEL), a highly aggressive cancer caused by Kaposi's sarcoma-associated herpesvirus. CMs bind to cereblon (CRBN), the substrate receptor of the cullin-RING type E3 ubiquitin ligase CRL4

Identifiants

DOI: 10.1182/bloodadvances.2019031732 PMID: 31300418 PMC: PMC6650732
pubmed: 31300418
pii: bloodadvances.2019031732
doi: 10.1182/bloodadvances.2019031732
pmc: PMC6650732
doi:

Substances chimiques

Adaptor Proteins, Signal Transducing 0
CRBN protein, human 0
CUL4A protein, human 0
CUL4B protein, human 0
Cullin Proteins 0
Thalidomide 4Z8R6ORS6L
pomalidomide D2UX06XLB5
Ubiquitin-Protein Ligases EC 2.3.2.27
Endopeptidases EC 3.4.-
SENP8 protein, human EC 3.4.22.-
Lenalidomide F0P408N6V4

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2105-2117

Subventions

Organisme : NCI NIH HHS
ID : R21 CA210904
Pays : United States

Informations de copyright

© 2019 by The American Society of Hematology.

Références

Cell. 2010 Dec 10;143(6):951-65
pubmed: 21145461
Nature. 2014 Aug 7;512(7512):49-53
pubmed: 25043012
Annu Rev Pathol. 2014;9:349-72
pubmed: 24111911
Nat Biotechnol. 2016 Feb;34(2):184-191
pubmed: 26780180
Blood. 2015 Aug 6;126(6):779-89
pubmed: 26002965
Mol Cell. 2007 Jun 22;26(6):775-80
pubmed: 17588513
Science. 2014 Jan 17;343(6168):301-5
pubmed: 24292625
Science. 2001 May 18;292(5520):1382-5
pubmed: 11337588
Nature. 2015 Jul 9;523(7559):183-188
pubmed: 26131937
Elife. 2018 Sep 20;7:
pubmed: 30234487
Science. 2014 Jan 17;343(6168):305-9
pubmed: 24292623
Mol Cell. 2012 Aug 10;47(3):371-82
pubmed: 22748924
Cell. 2013 Mar 28;153(1):206-15
pubmed: 23453757
Blood. 1996 Jul 15;88(2):645-56
pubmed: 8695812
Science. 2014 Jan 3;343(6166):84-87
pubmed: 24336571
Elife. 2018 Jun 18;7:
pubmed: 29911972
Nature. 2008 Jul 10;454(7201):226-31
pubmed: 18568025
Genes Dev. 1998 Aug 1;12(15):2263-8
pubmed: 9694792
Nat Commun. 2018 Aug 15;9(1):3263
pubmed: 30111820
Nature. 2016 Mar 31;531(7596):598-603
pubmed: 27029275
Genome Biol. 2015 Dec 16;16:281
pubmed: 26673418
Cell. 2017 Nov 30;171(6):1326-1339.e14
pubmed: 29103612
Br J Haematol. 2014 Mar;164(6):811-21
pubmed: 24328678
Genome Biol. 2014;15(12):554
pubmed: 25476604
J Clin Oncol. 2005 Jul 1;23(19):4372-80
pubmed: 15994147
Intractable Rare Dis Res. 2014 Aug;3(3):65-74
pubmed: 25364646
Oncogene. 2016 Apr 7;35(14):1797-810
pubmed: 26119939
Nature. 2006 Oct 5;443(7111):590-3
pubmed: 16964240
N Engl J Med. 1995 May 4;332(18):1186-91
pubmed: 7700311
EMBO Rep. 2013 Dec;14(12):1050-61
pubmed: 24232186
Leukemia. 2019 Jan;33(1):171-180
pubmed: 30026574
Blood. 2018 Sep 20;132(12):1293-1303
pubmed: 30042095
Nat Methods. 2014 Aug;11(8):783-784
pubmed: 25075903
J Clin Pharmacol. 2007 Dec;47(12):1466-75
pubmed: 17954615
Science. 2014 Jan 3;343(6166):80-4
pubmed: 24336569
Nature. 2016 Apr 7;532(7597):127-30
pubmed: 26909574
Elife. 2017 May 05;6:
pubmed: 28475037
Nat Struct Mol Biol. 2014 Sep;21(9):803-9
pubmed: 25108355
J Clin Pharmacol. 2015 Feb;55(2):168-78
pubmed: 25159194
Nat Rev Mol Cell Biol. 2005 Jan;6(1):9-20
pubmed: 15688063
Science. 2010 Mar 12;327(5971):1345-50
pubmed: 20223979
Cell. 2008 Sep 19;134(6):995-1006
pubmed: 18805092
Blood. 2018 Aug 9;132(6):577-586
pubmed: 29954751
Genomics. 2010 Aug;96(2):102-11
pubmed: 20580816
Annu Rev Biochem. 1998;67:425-79
pubmed: 9759494

Auteurs

Ajinkya Patil (A)

Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
ORCID: 0000-0003-1080-1146

Mark Manzano (M)

Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL.

Eva Gottwein (E)

Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Genome-wide CRISPR screens reveal genetic...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Systèmes CRISPR-Cas › Genome-wide CRISPR screens reveal genetic...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Séquences répétées en tandem › Clustered regularly interspaced short palindromic repeats › Genome-wide CRISPR screens reveal genetic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › Cullines › Genome-wide CRISPR screens reveal genetic...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › Genome-wide CRISPR screens reveal genetic...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Genome-wide CRISPR screens reveal genetic...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-down de gènes › Genome-wide CRISPR screens reveal genetic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genome-wide CRISPR screens reveal genetic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genome-wide CRISPR screens reveal genetic...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoindoles › Phtalimides › Lénalidomide › Genome-wide CRISPR screens reveal genetic...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Lymphomes › Lymphome malin non hodgkinien › Lymphome B › Lymphome primitif des séreuses › Genome-wide CRISPR screens reveal genetic...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Genome-wide CRISPR screens reveal genetic...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoindoles › Phtalimides › Thalidomide › Genome-wide CRISPR screens reveal genetic...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Ubiquitin-protein ligase complexes › Ubiquitin-protein ligases › Genome-wide CRISPR screens reveal genetic...