AP-1 Signaling by Fra-1 Directly Regulates HMGA1 Oncogene Transcription in Triple-Negative Breast Cancers.
Journal
Molecular cancer research : MCR
ISSN: 1557-3125
Titre abrégé: Mol Cancer Res
Pays: United States
ID NLM: 101150042
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
10
01
2019
revised:
29
05
2019
accepted:
08
07
2019
pubmed:
14
7
2019
medline:
17
7
2020
entrez:
14
7
2019
Statut:
ppublish
Résumé
The architectural chromatin protein HMGA1 and the transcription factor Fra-1 are both overexpressed in aggressive triple-negative breast cancers (TNBC), where they both favor epithelial-to-mesenchymal transition, invasion, and metastasis. We therefore explored the possibility that Fra-1 might be involved in enhanced transcription of the
Identifiants
pubmed: 31300541
pii: 1541-7786.MCR-19-0036
doi: 10.1158/1541-7786.MCR-19-0036
doi:
Substances chimiques
HMGA1 protein, human
0
Transcription Factor AP-1
0
HMGA1a Protein
124544-67-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1999-2014Informations de copyright
©2019 American Association for Cancer Research.