Impact of infant protein supply and other early life factors on plasma metabolome at 5.5 and 8 years of age: a randomized trial.
Biomarkers
/ blood
Child
Child, Preschool
Dietary Proteins
/ analysis
Double-Blind Method
Female
Humans
Infant
Infant Formula
/ statistics & numerical data
Infant Nutritional Physiological Phenomena
/ physiology
Infant, Newborn
Male
Maternal Exposure
/ statistics & numerical data
Metabolome
/ physiology
Pregnancy
Journal
International journal of obesity (2005)
ISSN: 1476-5497
Titre abrégé: Int J Obes (Lond)
Pays: England
ID NLM: 101256108
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
05
06
2018
accepted:
19
04
2019
revised:
06
01
2019
pubmed:
14
7
2019
medline:
1
12
2020
entrez:
14
7
2019
Statut:
ppublish
Résumé
A high dairy protein intake in infancy, maternal pre-pregnancy BMI, and delivery mode are documented early programming factors that modulate the later risk of obesity and other health outcomes, but the mechanisms of action are not understood. The Childhood Obesity Project is a European multicenter, double-blind, randomized clinical trial that enrolled healthy infants. Participating infants were either breastfed (BF) or randomized to receive higher (HP) or lower protein (LP) content formula in the first year of life. At the ages 5.5 years (n = 276) and 8 years (n = 232), we determined plasma metabolites by liquid chromatography tandem-mass-spectrometry of which 226 and 185 passed quality control at 5.5 years and 8 years, respectively. We assessed the effects of infant feeding, maternal pre-pregnancy BMI, smoking in pregnancy, delivery mode, parity, birth weight and length, and weight gain (0-24 months) on the metabolome at 5.5 and 8 years. At 5.5 years, plasma alpha-ketoglutarate and the acylcarnitine/BCAA ratios tended to be higher in the HP than in the LP group, but no metabolite reached statistical significance (P Plasma metabolome was largely unaffected by feeding choice and other early programming factors and we could not prove the existence of a long term programming effect of the plasma metabolome.
Identifiants
pubmed: 31300705
doi: 10.1038/s41366-019-0398-9
pii: 10.1038/s41366-019-0398-9
doi:
Substances chimiques
Biomarkers
0
Dietary Proteins
0
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
69-81Références
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