Increased pain and inflammatory sensitivity in growth hormone-releasing hormone (GHRH) knockout mice.
Colon
Growth hormone-releasing hormone knockout
Inflammation
Pain
Journal
Prostaglandins & other lipid mediators
ISSN: 1098-8823
Titre abrégé: Prostaglandins Other Lipid Mediat
Pays: United States
ID NLM: 9808648
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
15
03
2019
revised:
04
06
2019
accepted:
09
07
2019
pubmed:
14
7
2019
medline:
21
5
2020
entrez:
14
7
2019
Statut:
ppublish
Résumé
Growth hormone (GH) and GH-releasing hormone (GHRH), in addition to metabolic and endocrine effects, play a role in the modulation of pain and inflammation. We aimed to elucidate the consequences of GHRH deficiency on acute nociceptive stimulation and on both acute and chronic inflammatory stimuli in a mouse model of GH deficiency. Mice with generalized ablation of the GHRH gene (GHRH knock out, GHRHKO, -/-) were compared to wild type (GHRH +/+) mice. Responsiveness to acute nociceptive stimulation and to acute inflammatory stimulation was evaluated by conventional hot plate apparatus and formalin test, respectively. We also evaluated responsiveness to colonic inflammation induced both in vivo, after dextran sodium sulfate (DSS) treatment, or ex vivo, by incubating colon segments with bacterial lipopolysaccaride (LPS). Macroscopical and histological examinations were performed, prostaglandin (PG) E
Identifiants
pubmed: 31301405
pii: S1098-8823(19)30047-4
doi: 10.1016/j.prostaglandins.2019.106362
pii:
doi:
Substances chimiques
Tumor Necrosis Factor-alpha
0
8-epi-prostaglandin F2alpha
27415-26-5
Growth Hormone-Releasing Hormone
9034-39-3
Dinoprost
B7IN85G1HY
Cyclooxygenase 2
EC 1.14.99.1
Dinoprostone
K7Q1JQR04M
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106362Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.