Synthesis and assessment of phenylacrylamide derivatives as potential anti-oxidant and anti-inflammatory agents.
Acrylamide
/ chemical synthesis
Anti-Inflammatory Agents, Non-Steroidal
/ chemical synthesis
Antioxidants
/ chemical synthesis
Cell Survival
/ drug effects
Dose-Response Relationship, Drug
HEK293 Cells
Humans
Hydrogen Peroxide
/ antagonists & inhibitors
Inflammation
/ drug therapy
Molecular Structure
Oxidative Stress
/ drug effects
Structure-Activity Relationship
Anti-oxidant and anti-inflammatory agent
Inflammation
Nrf2
Oxidative stress
Phenylacrylamide derivatives
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
15 Oct 2019
15 Oct 2019
Historique:
received:
07
04
2019
revised:
04
07
2019
accepted:
06
07
2019
pubmed:
14
7
2019
medline:
5
11
2019
entrez:
14
7
2019
Statut:
ppublish
Résumé
Oxidative stress and inflammation are major causes of numerous life-threatening human diseases. In the present study, we synthesized a series of phenylacrylamide derivatives as novel anti-oxidant and anti-inflammatory agents. Biological evaluation showed that compound 6a could more potently protect HBZY-1 mesangial cells from H
Identifiants
pubmed: 31301564
pii: S0223-5234(19)30641-5
doi: 10.1016/j.ejmech.2019.07.020
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Antioxidants
0
Acrylamide
20R035KLCI
Hydrogen Peroxide
BBX060AN9V
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
62-71Informations de copyright
Copyright © 2019 Elsevier Masson SAS. All rights reserved.