A pilot study: Bisphenol-A and Bisphenol-A glucuronide levels in mother and child pairs in a South African population.
Adolescent
Adult
Benzhydryl Compounds
/ blood
Chromatography, Liquid
Cohort Studies
Environmental Exposure
/ analysis
Female
Fetal Blood
/ chemistry
Gestational Age
Glucuronides
/ blood
Humans
Infant, Newborn
Limit of Detection
Male
Maternal-Fetal Exchange
Phenols
/ blood
Pilot Projects
Pregnancy
Pregnancy Trimester, Third
South Africa
Tandem Mass Spectrometry
Young Adult
Bisphenol A
Cord blood
Liquid chromatography tandem mass spectrometry
Mother-child pairs
Journal
Reproductive toxicology (Elmsford, N.Y.)
ISSN: 1873-1708
Titre abrégé: Reprod Toxicol
Pays: United States
ID NLM: 8803591
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
05
02
2019
revised:
03
07
2019
accepted:
10
07
2019
pubmed:
16
7
2019
medline:
12
5
2020
entrez:
15
7
2019
Statut:
ppublish
Résumé
Exposure to Bisphenol A (BPA) during early development particularly in- utero has been linked to a wide range of pathology. The aim of this study was to determine serum levels of BPA and its naturally occurring metabolite BPA-glucuronide (BPA-g) in South African mother-child pairs. Third-trimester serum maternal samples and matching cord blood samples were analysed for BPA and BPA-g using LC-MS/MS. Ninety maternal and child pairs were analysed. BPA was detectable in more than 25% of maternal and cord blood samples. Spearman correlation demonstrated significant positive correlation between maternal and child BPA and BPA-g levels with correlation coefficients of 0.892 and 0.744, respectively. A significant positive association between cord BPA levels and child birth-weight (p = 0.02) as well as with maternal BMI (p = 0.04) was noted. This is the first study to describe the presence of detectable BPA levels using LC-MS/MS methodology in a South African population.
Identifiants
pubmed: 31302198
pii: S0890-6238(19)30038-3
doi: 10.1016/j.reprotox.2019.07.008
pii:
doi:
Substances chimiques
Benzhydryl Compounds
0
Glucuronides
0
Phenols
0
bisphenol A glucuronide
0
bisphenol A
MLT3645I99
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
93-99Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.