The endocannabinoid system is affected by cholesterol dyshomeostasis: Insights from a murine model of Niemann Pick type C disease.

Animals Brain / metabolism Cholesterol / metabolism Disease Models, Animal Endocannabinoids / metabolism Homeostasis / physiology Mice Niemann-Pick Disease, Type C / metabolism Receptor, Cannabinoid, CB1 / metabolism Receptor, Cannabinoid, CB2 / metabolism
Behavioral phenotyping Endocannabinoid system biochemistry Genetic mouse models Lysosomal storage disorders

Journal

Neurobiology of disease
ISSN: 1095-953X
Titre abrégé: Neurobiol Dis
Pays: United States
ID NLM: 9500169

Informations de publication

Date de publication:
10 2019
Historique:
received: 05 03 2019
revised: 25 06 2019
accepted: 10 07 2019
pubmed: 16 7 2019
medline: 25 3 2020
entrez: 15 7 2019
Statut: ppublish

Résumé

The dyshomeostasis of intracellular cholesterol trafficking is typical of the Niemann-Pick type C (NPC) disease, a fatal inherited lysosomal storage disorder presenting with progressive neurodegeneration and visceral organ involvement. In light of the well-established relevance of cholesterol in regulating the endocannabinoid (eCB) system expression and activity, this study was aimed at elucidating whether NPC disease-related cholesterol dyshomeostasis affects the functional status of the brain eCB system. To this end, we exploited a murine model of NPC deficiency for determining changes in the expression and activity of the major molecular components of the eCB signaling, including cannabinoid type-1 and type-2 (CB

Identifiants

DOI: 10.1016/j.nbd.2019.104531 PMID: 31302243
pubmed: 31302243
pii: S0969-9961(19)30199-8
doi: 10.1016/j.nbd.2019.104531
pii:
doi:

Substances chimiques

Endocannabinoids 0
Receptor, Cannabinoid, CB1 0
Receptor, Cannabinoid, CB2 0
Cholesterol 97C5T2UQ7J

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

104531

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Sergio Oddi (S)

Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy; Fondazione Santa Lucia, IRCCS, Via del Fosso di Fiorano 64, 00179, Italy.

Paola Caporali (P)

Department of Psychology, Division of Neuroscience and "Daniel Bovet" Neurobiology Research Center, Sapienza University of Rome, Via dei Sardi 70, 00185 Rome, Italy.

Jessica Dragotto (J)

Department of Psychology, Division of Neuroscience and "Daniel Bovet" Neurobiology Research Center, Sapienza University of Rome, Via dei Sardi 70, 00185 Rome, Italy.

Antonio Totaro (A)

Fondazione Santa Lucia, IRCCS, Via del Fosso di Fiorano 64, 00179, Italy.

Marzia Maiolati (M)

Department of Psychology, Division of Neuroscience and "Daniel Bovet" Neurobiology Research Center, Sapienza University of Rome, Via dei Sardi 70, 00185 Rome, Italy.

Lucia Scipioni (L)

Fondazione Santa Lucia, IRCCS, Via del Fosso di Fiorano 64, 00179, Italy.

Clotilde Beatrice Angelucci (CB)

Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.

Cristina Orsini (C)

Fondazione Santa Lucia, IRCCS, Via del Fosso di Fiorano 64, 00179, Italy; Department of Psychology, Division of Neuroscience and "Daniel Bovet" Neurobiology Research Center, Sapienza University of Rome, Via dei Sardi 70, 00185 Rome, Italy.

Sonia Canterini (S)

Department of Psychology, Division of Neuroscience and "Daniel Bovet" Neurobiology Research Center, Sapienza University of Rome, Via dei Sardi 70, 00185 Rome, Italy.

Cinzia Rapino (C)

Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.

Mauro Maccarrone (M)

Fondazione Santa Lucia, IRCCS, Via del Fosso di Fiorano 64, 00179, Italy; Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.

Maria Teresa Fiorenza (MT)

Fondazione Santa Lucia, IRCCS, Via del Fosso di Fiorano 64, 00179, Italy; Department of Psychology, Division of Neuroscience and "Daniel Bovet" Neurobiology Research Center, Sapienza University of Rome, Via dei Sardi 70, 00185 Rome, Italy. Electronic address: mariateresa.fiorenza@uniroma1.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The endocannabinoid system is affected by...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › The endocannabinoid system is affected by...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › The endocannabinoid system is affected by...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › The endocannabinoid system is affected by...
questionsmedicales.fr › Lipides › Acides gras › Endocannabinoïdes › The endocannabinoid system is affected by...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › The endocannabinoid system is affected by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The endocannabinoid system is affected by...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Erreurs innées du métabolisme › Maladies lysosomiales › Maladies neurologiques de surcharge lysosomiale › Sphingolipidoses › Maladies de Niemann-Pick › Maladie de Niemann-Pick de type C › The endocannabinoid system is affected by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs de cannabinoïdes › Récepteur cannabinoïde de type CB1 › The endocannabinoid system is affected by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs de cannabinoïdes › Récepteur cannabinoïde de type CB2 › The endocannabinoid system is affected by...