Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review.
Acute Pain
/ drug therapy
Analgesics
/ pharmacology
Anesthetics, Local
/ pharmacology
Anti-Inflammatory Agents, Non-Steroidal
/ pharmacology
Chronic Pain
/ drug therapy
Humans
Ion Channels
/ drug effects
Lidocaine
/ pharmacology
Molecular Targeted Therapy
/ methods
Synaptic Transmission
/ drug effects
acute pain
analgesia
inflammation
lidocaine
local anaesthetics
neuropathic pain
neurotransmitter
Journal
British journal of anaesthesia
ISSN: 1471-6771
Titre abrégé: Br J Anaesth
Pays: England
ID NLM: 0372541
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
02
01
2019
revised:
03
06
2019
accepted:
03
06
2019
pubmed:
16
7
2019
medline:
27
8
2019
entrez:
16
7
2019
Statut:
ppublish
Résumé
Systemic administration of the local anaesthetic lidocaine is antinociceptive in both acute and chronic pain states, especially in acute postoperative and chronic neuropathic pain. These effects cannot be explained by its voltage-gated sodium channel blocking properties alone, but the responsible mechanisms are still elusive. This narrative review focuses on available experimental evidence of the molecular mechanisms by which systemic lidocaine exerts its clinically documented analgesic effects. These include effects on the peripheral nervous system and CNS, where lidocaine acts via silencing ectopic discharges, suppression of inflammatory processes, and modulation of inhibitory and excitatory neurotransmission. We highlight promising objectives for future research to further unravel these antinociceptive mechanisms, which subsequently may facilitate the development of new analgesic strategies and therapies for acute and chronic pain.
Identifiants
pubmed: 31303268
pii: S0007-0912(19)30501-X
doi: 10.1016/j.bja.2019.06.014
pii:
doi:
Substances chimiques
Analgesics
0
Anesthetics, Local
0
Anti-Inflammatory Agents, Non-Steroidal
0
Ion Channels
0
Lidocaine
98PI200987
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
335-349Informations de copyright
Copyright © 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.