Soluble UL16-binding protein 2 is associated with a poor prognosis in pancreatic cancer patients.
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
/ analysis
Cell Line, Tumor
Female
GPI-Linked Proteins
/ analysis
Humans
Intercellular Signaling Peptides and Proteins
/ analysis
Killer Cells, Natural
/ pathology
Male
Middle Aged
Pancreas
/ pathology
Pancreatic Neoplasms
/ blood
Prognosis
Survival Analysis
Cytotoxicity
NK cells
NKG2D
Pancreatic cancer
Prognosis
Soluble ULBP2
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
10 09 2019
10 09 2019
Historique:
received:
02
07
2019
accepted:
05
07
2019
pubmed:
16
7
2019
medline:
22
5
2020
entrez:
16
7
2019
Statut:
ppublish
Résumé
The immune system plays important roles in pancreatic cancer. MHC class I-chain-related proteins A and B (MICA/B) and UL16-binding proteins (ULBPs) are known natural killer group 2D (NKG2D) ligands. Soluble NKG2D ligands can inhibit the activation of Natural killer (NK) cells. In pancreatic cancer, soluble ULBPs are relatively unstudied in contrast to soluble MICA/B. We examined the significance of soluble ULBPs, especially ULBP2, in pancreatic cancer. Soluble ULBP2 but neither soluble ULBP1 nor soluble ULBP3, was etected in the supernatants of pancreatic cancer cells. Soluble ULBP2 derived from pancreatic cancer cells could reduce the cytotoxicity of NK cells. Multivariate analysis demonstrated that serum soluble ULBP2 was a significant independent factor associated with poor overall survival (OS) in all pancreatic cancer patients, specifically in stage IV patients. In conclusion, pancreatic cancer-derived soluble ULBP2 might affect the prognosis in pancreatic cancer.
Identifiants
pubmed: 31303272
pii: S0006-291X(19)31356-7
doi: 10.1016/j.bbrc.2019.07.020
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
GPI-Linked Proteins
0
Intercellular Signaling Peptides and Proteins
0
ULBP2 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
84-88Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.