Targeting MUC1-C Inhibits TWIST1 Signaling in Triple-Negative Breast Cancer.
Cell Line, Tumor
Cell Self Renewal
/ drug effects
Drug Resistance, Neoplasm
Epithelial-Mesenchymal Transition
Female
Gene Expression Regulation, Neoplastic
/ drug effects
Humans
Mucin-1
/ metabolism
Neoplastic Stem Cells
/ metabolism
Nuclear Proteins
/ genetics
Paclitaxel
/ pharmacology
Signal Transduction
Triple Negative Breast Neoplasms
/ drug therapy
Twist-Related Protein 1
/ genetics
Journal
Molecular cancer therapeutics
ISSN: 1538-8514
Titre abrégé: Mol Cancer Ther
Pays: United States
ID NLM: 101132535
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
14
02
2019
revised:
21
05
2019
accepted:
08
07
2019
pubmed:
17
7
2019
medline:
10
6
2020
entrez:
17
7
2019
Statut:
ppublish
Résumé
The oncogenic MUC1-C protein and the TWIST1 epithelial-mesenchymal transition transcription factor (EMT-TF) are aberrantly expressed in triple-negative breast cancer (TNBC) cells. However, there is no known association between MUC1-C and TWIST1 in TNBC or other cancer cells. Here, we show that MUC1-C activates STAT3, and that MUC1-C and pSTAT3 drive induction of the
Identifiants
pubmed: 31308076
pii: 1535-7163.MCT-19-0156
doi: 10.1158/1535-7163.MCT-19-0156
pmc: PMC6774902
mid: NIHMS1534725
doi:
Substances chimiques
MUC1 protein, human
0
Mucin-1
0
Nuclear Proteins
0
TWIST1 protein, human
0
Twist-Related Protein 1
0
Paclitaxel
P88XT4IS4D
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1744-1754Subventions
Organisme : NCI NIH HHS
ID : R01 CA097098
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA166480
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA216553
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA229716
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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