Identifying New Substrates and Functions for an Old Enzyme: Calcineurin.
Amino Acid Motifs
Animals
Calcineurin
/ chemistry
Calcineurin Inhibitors
/ chemistry
Calcium
/ metabolism
Computer Simulation
Cyclosporine
/ metabolism
Gene Expression Regulation
Humans
Hypertension
/ therapy
Immune System
Immunosuppression Therapy
Immunosuppressive Agents
Isoenzymes
/ chemistry
NFATC Transcription Factors
/ metabolism
Nuclear Proteins
/ metabolism
Phosphoric Monoester Hydrolases
/ metabolism
Phosphorylation
Protein Conformation
Protein Isoforms
Proteomics
/ methods
Signal Transduction
Tacrolimus
/ pharmacology
Journal
Cold Spring Harbor perspectives in biology
ISSN: 1943-0264
Titre abrégé: Cold Spring Harb Perspect Biol
Pays: United States
ID NLM: 101513680
Informations de publication
Date de publication:
02 03 2020
02 03 2020
Historique:
pubmed:
17
7
2019
medline:
3
8
2021
entrez:
17
7
2019
Statut:
epublish
Résumé
Biological processes are dynamically regulated by signaling networks composed of protein kinases and phosphatases. Calcineurin, or PP3, is a conserved phosphoserine/phosphothreonine-specific protein phosphatase and member of the PPP family of phosphatases. Calcineurin is unique, however, in its activation by Ca
Identifiants
pubmed: 31308145
pii: cshperspect.a035436
doi: 10.1101/cshperspect.a035436
pmc: PMC7050593
pii:
doi:
Substances chimiques
Calcineurin Inhibitors
0
Immunosuppressive Agents
0
Isoenzymes
0
NFATC Transcription Factors
0
Nuclear Proteins
0
Protein Isoforms
0
Cyclosporine
83HN0GTJ6D
Calcineurin
EC 3.1.3.16
Phosphoric Monoester Hydrolases
EC 3.1.3.2
Calcium
SY7Q814VUP
Tacrolimus
WM0HAQ4WNM
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM119336
Pays : United States
Informations de copyright
Copyright © 2020 Cold Spring Harbor Laboratory Press; all rights reserved.
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