Effect of Treatment on Damage and Hospitalization in Elderly Patients with Microscopic Polyangiitis and Granulomatosis with Polyangiitis.

Aged Antibodies, Antineutrophil Cytoplasmic Granulomatosis with Polyangiitis / complications Hospitalization Humans Microscopic Polyangiitis / drug therapy Peroxidase
ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS GRANULOMATOSIS WITH POLYANGIITIS HOSPITALIZATION MICROSCOPIC POLYANGIITIS

Journal

The Journal of rheumatology
ISSN: 0315-162X
Titre abrégé: J Rheumatol
Pays: Canada
ID NLM: 7501984

Informations de publication

Date de publication:
04 2020
Historique:
accepted: 25 06 2019
pubmed: 17 7 2019
medline: 1 9 2021
entrez: 17 7 2019
Statut: ppublish

Résumé

Age is a risk factor for organ damage, adverse events, and mortality in microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA). However, the relationship between treatment and damage, hospitalizations, and causes of death in elderly patients is largely unknown. Consecutive patients from Sweden, the United Kingdom, and the Czech Republic diagnosed between 1997 and 2013 were included. Inclusion criteria were a diagnosis of MPA or GPA and age 75 years or more at diagnosis. Treatment with cyclophosphamide (CYC), rituximab (RTX), and corticosteroids the first 3 months was registered. Outcomes up to 2 years from diagnosis included Vasculitis Damage Index (VDI), hospitalization, and cause of death. Treatment data were available for 167 of 202 patients. At 2 years, 4% had no items of damage. There was a positive association between VDI score at 2 years and Birmingham Vasculitis Activity Score at onset, and a negative association with treatment using CYC or RTX. Intravenous methylprednisolone dose was associated with treatment-related damage. During the first year, 69% of patients were readmitted to hospital. Myeloperoxidase-antineutrophil cytoplasmic antibody positivity and lower creatinine levels decreased the odds of readmission. The most common cause of death was infection, and this was associated with cumulative oral prednisolone dose. Immunosuppressive treatment with CYC or RTX in elderly patients with MPA and GPA was associated with development of less permanent organ damage and was not associated with hospitalization. However, higher doses of corticosteroids during the first 3 months was associated with treatment-related damage and fatal infections.

Identifiants

DOI: 10.3899/jrheum.190019 PMID: 31308208
pubmed: 31308208
pii: jrheum.190019
doi: 10.3899/jrheum.190019
doi:

Substances chimiques

Antibodies, Antineutrophil Cytoplasmic 0
Peroxidase EC 1.11.1.7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

580-588

Auteurs

Maria Weiner (M)

From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore. maria.weiner@liu.se.
M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University. maria.weiner@liu.se.

Su Mein Goh (SM)

From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore.
M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University.

Aladdin J Mohammad (AJ)

From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore.
M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University.
ORCID: 0000-0002-7169-6936

Zdenka Hrušková (Z)

From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore.
M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University.
ORCID: 0000-0002-2658-365X

Anisha Tanna (A)

From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore.
M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University.

Phoebe Sharp (P)

From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore.
M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University.

Amy Kang (A)

From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore.
M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University.

Annette Bruchfeld (A)

From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore.
M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University.
ORCID: 0000-0002-9752-9941

Daina Selga (D)

From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore.
M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University.

Zdeňka Chocová (Z)

From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore.
M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University.

Kerstin Westman (K)

From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore.
M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University.
ORCID: 0000-0002-2930-998X

Per Eriksson (P)

From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore.
M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University.

Lorraine Harper (L)

From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore.
M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University.

Charles D Pusey (CD)

From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore.
M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University.

Vladimír Tesař (V)

From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore.
M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University.
ORCID: 0000-0001-6982-0689

Alan D Salama (AD)

From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore.
M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University.
ORCID: 0000-0002-9255-9092

Mårten Segelmark (M)

From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore.
M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University.
ORCID: 0000-0002-1221-0772

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Effect of Treatment on Damage and...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Anticorps anti-cytoplasme des polynucléaires neutrophiles › Effect of Treatment on Damage and...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Vascularites associées aux anticorps anti-cytoplasme des neutrophiles › Granulomatose avec polyangéite › Effect of Treatment on Damage and...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Soins aux patients › Hospitalisation › Effect of Treatment on Damage and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effect of Treatment on Damage and...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Vascularites associées aux anticorps anti-cytoplasme des neutrophiles › Polyangéite microscopique › Effect of Treatment on Damage and...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Peroxidases › Myeloperoxidase › Effect of Treatment on Damage and...