An immunometabolic pathomechanism for chronic obstructive pulmonary disease.
COPD
immunometabolism
leptin
regulatory T cells
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
30 07 2019
30 07 2019
Historique:
pubmed:
17
7
2019
medline:
25
3
2020
entrez:
17
7
2019
Statut:
ppublish
Résumé
Chronic obstructive pulmonary disease (COPD) is an inflammatory condition associated with abnormal immune responses, leading to airflow obstruction. Lungs of COPD subjects show accumulation of proinflammatory T helper (Th) 1 and Th17 cells resembling that of autoreactive immune responses. As regulatory T (T
Identifiants
pubmed: 31308239
pii: 1906303116
doi: 10.1073/pnas.1906303116
pmc: PMC6681742
doi:
Substances chimiques
FOXP3 protein, human
0
Forkhead Transcription Factors
0
LEP protein, human
0
Leptin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15625-15634Subventions
Organisme : European Research Council
ID : 310496
Pays : International
Informations de copyright
Copyright © 2019 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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