Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.

Adult Anorexia Nervosa / etiology Body Mass Index Case-Control Studies Female Genetic Predisposition to Disease Genome-Wide Association Study Genomics / methods Humans Male Mental Disorders / complications Metabolic Diseases / complications Phenotype Prognosis Quantitative Trait Loci

Journal

Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904

Informations de publication

Date de publication:
08 2019
Historique:
received: 09 06 2018
accepted: 14 05 2019
pubmed: 17 7 2019
medline: 29 1 2020
entrez: 17 7 2019
Statut: ppublish

Résumé

Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness

Identifiants

DOI: 10.1038/s41588-019-0439-2 PMID: 31308545 PMC: PMC6779477
pubmed: 31308545
doi: 10.1038/s41588-019-0439-2
pii: 10.1038/s41588-019-0439-2
pmc: PMC6779477
mid: NIHMS1049606
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1207-1214

Subventions

Organisme : NIMH NIH HHS
ID : R21 MH104831
Pays : United States
Organisme : NIAAA NIH HHS
ID : K01 AA025113
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH109536
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH109772
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG006830
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH109782
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH106675
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH106611
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH092793
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH109528
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH115397
Pays : United States

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Auteurs

Hunna J Watson (HJ)

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
School of Psychology, Curtin University, Perth, Western Australia, Australia.
School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia.
ORCID: 0000-0001-8405-381X

Zeynep Yilmaz (Z)

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Laura M Thornton (LM)

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Christopher Hübel (C)

Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0002-1267-8287

Jonathan R I Coleman (JRI)

Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
National Institute for Health Research Biomedical Research Centre, King's College London and South London and Maudsley National Health Service Foundation Trust, London, UK.
ORCID: 0000-0002-6759-0944

Héléna A Gaspar (HA)

Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
National Institute for Health Research Biomedical Research Centre, King's College London and South London and Maudsley National Health Service Foundation Trust, London, UK.
ORCID: 0000-0002-5540-2707

Julien Bryois (J)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Anke Hinney (A)

Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Virpi M Leppä (VM)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Manuel Mattheisen (M)

Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Center for Psychiatry Research, Stockholm Health Care Services, Stockholm City Council, Stockholm, Sweden.
Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany.

Sarah E Medland (SE)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
ORCID: 0000-0003-1382-380X

Stephan Ripke (S)

Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Stanley Center for Psychiatric Research, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany.

Shuyang Yao (S)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Paola Giusti-Rodríguez (P)

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Ken B Hanscombe (KB)

Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London, UK.

Kirstin L Purves (KL)

Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
ORCID: 0000-0002-8110-5554

Roger A H Adan (RAH)

Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands.
Center for Eating Disorders Rintveld, Altrecht Mental Health Institute, Zeist, the Netherlands.
Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Lars Alfredsson (L)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Tetsuya Ando (T)

Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.

Ole A Andreassen (OA)

NORMENT KG Jebsen Centre, Division of Mental Health and Addiction, University of Oslo, Oslo University Hospital, Oslo, Norway.

Jessica H Baker (JH)

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Wade H Berrettini (WH)

Department of Psychiatry, Center for Neurobiology and Behavior, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Ilka Boehm (I)

Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.

Claudette Boni (C)

INSERM 1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.

Vesna Boraska Perica (VB)

Wellcome Sanger Institute, Hinxton, UK.
Department of Medical Biology, School of Medicine, University of Split, Split, Croatia.

Katharina Buehren (K)

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.

Roland Burghardt (R)

Department of Child and Adolescent Psychiatry, Klinikum Frankfurt/Oder, Frankfurt, Germany.

Matteo Cassina (M)

Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Padova, Italy.

Sven Cichon (S)

Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.

Maurizio Clementi (M)

Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Padova, Italy.

Roger D Cone (RD)

Life Sciences Institute and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.

Philippe Courtet (P)

Department of Emergency Psychiatry and Post-Acute Care, CHRU Montpellier, University of Montpellier, Montpellier, France.

Scott Crow (S)

Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA.

James J Crowley (JJ)

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Unna N Danner (UN)

Center for Eating Disorders Rintveld, Altrecht Mental Health Institute, Zeist, the Netherlands.

Oliver S P Davis (OSP)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
School of Social and Community Medicine, University of Bristol, Bristol, UK.

Martina de Zwaan (M)

Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany.

George Dedoussis (G)

Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.

Daniela Degortes (D)

Department of Neurosciences, University of Padova, Padova, Italy.

Janiece E DeSocio (JE)

College of Nursing, Seattle University, Seattle, WA, USA.

Danielle M Dick (DM)

Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA.

Dimitris Dikeos (D)

Department of Psychiatry, Athens University Medical School, Athens University, Athens, Greece.

Christian Dina (C)

L'institut du thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, Nantes, France.

Monika Dmitrzak-Weglarz (M)

Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.

Elisa Docampo (E)

Barcelona Institute of Science and Technology, Barcelona, Spain.
Universitat Pompeu Fabra, Barcelona, Spain.
Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.

Laramie E Duncan (LE)

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.

Karin Egberts (K)

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Centre for Mental Health, Würzburg, Germany.

Stefan Ehrlich (S)

Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.

Geòrgia Escaramís (G)

Barcelona Institute of Science and Technology, Barcelona, Spain.
Universitat Pompeu Fabra, Barcelona, Spain.
Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.

Tõnu Esko (T)

Estonian Genome Center, University of Tartu, Tartu, Estonia.
Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.

Xavier Estivill (X)

Barcelona Institute of Science and Technology, Barcelona, Spain.
Universitat Pompeu Fabra, Barcelona, Spain.
Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
Genomics and Disease, Bioinformatics and Genomics Programme, Centre for Genomic Regulation, Barcelona, Spain.

Anne Farmer (A)

Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.

Angela Favaro (A)

Department of Neurosciences, University of Padova, Padova, Italy.

Fernando Fernández-Aranda (F)

Department of Psychiatry, University Hospital of Bellvitge -IDIBELL and CIBERobn, Barcelona, Spain.
Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain.

Manfred M Fichter (MM)

Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University (LMU), Munich, Germany.
Schön Klinik Roseneck affiliated with the Medical Faculty of the University of Munich (LMU), Munich, Germany.

Krista Fischer (K)

Estonian Genome Center, University of Tartu, Tartu, Estonia.

Manuel Föcker (M)

Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Lenka Foretova (L)

Department of Cancer, Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

Andreas J Forstner (AJ)

Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
Department of Psychiatry (UPK), University of Basel, Basel, Switzerland.
Department of Biomedicine, University of Basel, Basel, Switzerland.

Monica Forzan (M)

Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Padova, Italy.

Christopher S Franklin (CS)

Wellcome Sanger Institute, Hinxton, UK.

Steven Gallinger (S)

Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Ina Giegling (I)

Department of Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University of Halle-Wittenberg, Halle, Germany.

Johanna Giuranna (J)

Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Fragiskos Gonidakis (F)

First Psychiatric Department, National and Kapodistrian University of Athens, Medical School, Eginition Hospital, Athens, Greece.

Philip Gorwood (P)

INSERM 1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.
CMME, Hôpital Sainte-Anne (GHU Paris Psychiatrie et Neurosciences), Paris Descartes University, Paris, France.

Monica Gratacos Mayora (MG)

Barcelona Institute of Science and Technology, Barcelona, Spain.
Universitat Pompeu Fabra, Barcelona, Spain.
Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.

Sébastien Guillaume (S)

Department of Emergency Psychiatry and Post-Acute Care, CHRU Montpellier, University of Montpellier, Montpellier, France.

Yiran Guo (Y)

Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Hakon Hakonarson (H)

Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Konstantinos Hatzikotoulas (K)

Wellcome Sanger Institute, Hinxton, UK.
Institute of Translational Genomics, Helmholtz Zentrum München, Neuherberg, Germany.

Joanna Hauser (J)

Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.

Johannes Hebebrand (J)

Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Sietske G Helder (SG)

Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
Zorg op Orde, Leidschendam, the Netherlands.

Stefan Herms (S)

Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
Department of Biomedicine, University of Basel, Basel, Switzerland.

Beate Herpertz-Dahlmann (B)

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.

Wolfgang Herzog (W)

Department of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.

Laura M Huckins (LM)

Wellcome Sanger Institute, Hinxton, UK.
Department of Psychiatry, and Genetics and Genomics Sciences, Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

James I Hudson (JI)

Biological Psychiatry Laboratory, McLean Hospital/Harvard Medical School, Boston, MA, USA.

Hartmut Imgart (H)

Eating Disorders Unit, Parklandklinik, Bad Wildungen, Germany.

Hidetoshi Inoko (H)

Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, School of Medicine, Tokai University, Isehara, Japan.

Vladimir Janout (V)

Faculty of Health Sciences, Palacky University, Olomouc, Czech Republic.

Susana Jiménez-Murcia (S)

Department of Psychiatry, University Hospital of Bellvitge -IDIBELL and CIBERobn, Barcelona, Spain.
Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain.

Antonio Julià (A)

Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain.

Gursharan Kalsi (G)

Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.

Deborah Kaminská (D)

Department of Psychiatry, First Faculty of Medicine, Charles University, Prague, Czech Republic.

Jaakko Kaprio (J)

Department of Public Health, University of Helsinki, Helsinki, Finland.
Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.

Leila Karhunen (L)

Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.

Andreas Karwautz (A)

Eating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.

Martien J H Kas (MJH)

Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands.
Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, the Netherlands.

James L Kennedy (JL)

Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

Anna Keski-Rahkonen (A)

Department of Public Health, University of Helsinki, Helsinki, Finland.

Kirsty Kiezebrink (K)

Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.

Youl-Ri Kim (YR)

Department of Psychiatry, Seoul Paik Hospital, Inje University, Seoul, Korea.

Lars Klareskog (L)

Rheumatology Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

Kelly L Klump (KL)

Department of Psychology, Michigan State University, East Lansing, MI, USA.

Gun Peggy S Knudsen (GPS)

Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.

Maria C La Via (MC)

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Stephanie Le Hellard (S)

Department of Clinical Science, K.G. Jebsen Centre for Psychosis Research, Norwegian Centre for Mental Disorders Research (NORMENT), University of Bergen, Bergen, Norway.
Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
Department of Clinical Medicine, Laboratory Building, Haukeland University Hospital, Bergen, Norway.

Robert D Levitan (RD)

Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

Dong Li (D)

Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Lisa Lilenfeld (L)

American School of Professional Psychology, Argosy University, Northern Virginia, Arlington, VA, USA.

Bochao Danae Lin (BD)

Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands.

Jolanta Lissowska (J)

Department of Cancer Epidemiology and Prevention, M Skłodowska-Curie Cancer Center - Oncology Center, Warsaw, Poland.

Jurjen Luykx (J)

Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands.

Pierre J Magistretti (PJ)

BESE Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
Department of Psychiatry, University of Lausanne-University Hospital of Lausanne (UNIL-CHUV), Lausanne, Switzerland.

Mario Maj (M)

Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.

Katrin Mannik (K)

Estonian Genome Center, University of Tartu, Tartu, Estonia.
Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

Sara Marsal (S)

Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain.

Christian R Marshall (CR)

Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.

Morten Mattingsdal (M)

NORMENT KG Jebsen Centre, Division of Mental Health and Addiction, University of Oslo, Oslo University Hospital, Oslo, Norway.

Sara McDevitt (S)

Department of Psychiatry, University College Cork, Cork, Ireland.
HSE National Clinical Programme for Eating Disorders, Cork, Ireland.

Peter McGuffin (P)

Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.

Andres Metspalu (A)

Estonian Genome Center, University of Tartu, Tartu, Estonia.
Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.

Ingrid Meulenbelt (I)

Department of Biomedical Data Science, Leiden University Medical Centre, Leiden, the Netherlands.

Nadia Micali (N)

Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Division of Child and Adolescent Psychiatry, Geneva University Hospital, Geneva, Switzerland.
Great Ormond Street Institute of Child Health, University College London, London, UK.

Karen Mitchell (K)

National Center for PTSD, VA Boston Healthcare System, Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA.

Alessio Maria Monteleone (AM)

Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.

Palmiero Monteleone (P)

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Salerno, Italy.

Melissa A Munn-Chernoff (MA)

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Benedetta Nacmias (B)

Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.

Marie Navratilova (M)

Department of Cancer, Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

Ioanna Ntalla (I)

Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.

Julie K O'Toole (JK)

Kartini Clinic, Portland, OR, USA.

Roel A Ophoff (RA)

Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands.
Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA.

Leonid Padyukov (L)

Rheumatology Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

Aarno Palotie (A)

Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Center for Human Genome Research at the Massachusetts General Hospital, Boston, MA, USA.

Jacques Pantel (J)

INSERM 1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.

Hana Papezova (H)

Department of Psychiatry, First Faculty of Medicine, Charles University, Prague, Czech Republic.

Dalila Pinto (D)

Department of Psychiatry, and Genetics and Genomics Sciences, Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Raquel Rabionet (R)

Saint Joan de Déu Research Institute, Saint Joan de Déu Barcelona Children's Hospital, Barcelona, Spain.
Institute of Biomedicine (IBUB), University of Barcelona, Barcelona, Spain.
Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, Spain.

Anu Raevuori (A)

Department of Public Health, University of Helsinki, Helsinki, Finland.

Nicolas Ramoz (N)

INSERM 1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.

Ted Reichborn-Kjennerud (T)

Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Valdo Ricca (V)

Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.
Department of Health Science, University of Florence, Florence, Italy.

Samuli Ripatti (S)

Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
Department of Public Health, University of Helsinki, Helsinki, Finland.
Institute for Molecular Medicine Finland (FIMM), HiLIFE Unit, University of Helsinki, Helsinki, Finland.

Franziska Ritschel (F)

Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Eating Disorders Research and Treatment Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.

Marion Roberts (M)

Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
Department of Psychological Medicine, University of Otago, Christchurch, New Zealand.
Faculty of Medicine & Health Sciences, University of Aukland, Aukland, New Zealand.

Alessandro Rotondo (A)

Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnologies, University of Pisa, Pisa, Italy.

Dan Rujescu (D)

Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University (LMU), Munich, Germany.
Department of Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University of Halle-Wittenberg, Halle, Germany.

Filip Rybakowski (F)

Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.

Paolo Santonastaso (P)

Department of Neurosciences, Padua Neuroscience Center, University of Padova, Padova, Italy.

André Scherag (A)

Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital, Jena, Germany.

Stephen W Scherer (SW)

Department of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

Ulrike Schmidt (U)

National Institute for Health Research Biomedical Research Centre, King's College London and South London and Maudsley National Health Service Foundation Trust, London, UK.
Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, King's College London, London, UK.

Nicholas J Schork (NJ)

J. Craig Venter Institute (JCVI), La Jolla, CA, USA.

Alexandra Schosser (A)

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Jochen Seitz (J)

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.

Lenka Slachtova (L)

Department of Pediatrics and Center of Applied Genomics, First Faculty of Medicine, Charles University, Prague, Czech Republic.

P Eline Slagboom (PE)

Department of Biomedical Data Science, Leiden University Medical Centre, Leiden, the Netherlands.

Margarita C T Slof-Op 't Landt (MCT)

Center for Eating Disorders Ursula, Rivierduinen, Leiden, the Netherlands.
Department of Psychiatry, Leiden University Medical Centre, Leiden, the Netherlands.

Agnieszka Slopien (A)

Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.

Sandro Sorbi (S)

Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.
IRCSS Fondazione Don Carlo Gnocchi, Florence, Italy.

Beata Świątkowska (B)

Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland.

Jin P Szatkiewicz (JP)

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Ioanna Tachmazidou (I)

Wellcome Sanger Institute, Hinxton, UK.

Elena Tenconi (E)

Department of Neurosciences, University of Padova, Padova, Italy.

Alfonso Tortorella (A)

Department of Psychiatry, University of Naples SUN, Naples, Italy.
Department of Psychiatry, University of Perugia, Perugia, Italy.

Federica Tozzi (F)

Brain Sciences Department, Stremble Ventures, Limassol, Cyprus.

Janet Treasure (J)

National Institute for Health Research Biomedical Research Centre, King's College London and South London and Maudsley National Health Service Foundation Trust, London, UK.
Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, King's College London, London, UK.

Artemis Tsitsika (A)

Adolescent Health Unit, Second Department of Pediatrics, "P. & A. Kyriakou" Children's Hospital, University of Athens, Athens, Greece.

Marta Tyszkiewicz-Nwafor (M)

Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.

Konstantinos Tziouvas (K)

Pediatric Intensive Care Unit, "P. & A. Kyriakou" Children's Hospital, University of Athens, Athens, Greece.

Annemarie A van Elburg (AA)

Center for Eating Disorders Rintveld, Altrecht Mental Health Institute, Zeist, the Netherlands.
Faculty of Social and Behavioral Sciences, Utrecht University, Utrecht, the Netherlands.

Eric F van Furth (EF)

Center for Eating Disorders Ursula, Rivierduinen, Leiden, the Netherlands.
Department of Psychiatry, Leiden University Medical Centre, Leiden, the Netherlands.

Gudrun Wagner (G)

Eating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.

Esther Walton (E)

Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.

Elisabeth Widen (E)

Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.

Eleftheria Zeggini (E)

Wellcome Sanger Institute, Hinxton, UK.
Institute of Translational Genomics, Helmholtz Zentrum München, Neuherberg, Germany.

Stephanie Zerwas (S)

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Stephan Zipfel (S)

Department of Internal Medicine VI, Psychosomatic Medicine and Psychotherapy, University Medical Hospital Tuebingen, Tuebingen, Germany.

Andrew W Bergen (AW)

BioRealm, LLC, Walnut, CA, USA.
Oregon Research Institute, Eugene, OR, USA.

Joseph M Boden (JM)

Christchurch Health and Development Study, University of Otago, Christchurch, New Zealand.
ORCID: 0000-0003-1502-1608

Harry Brandt (H)

The Center for Eating Disorders at Sheppard Pratt, Baltimore, MD, USA.

Steven Crawford (S)

The Center for Eating Disorders at Sheppard Pratt, Baltimore, MD, USA.

Katherine A Halmi (KA)

Department of Psychiatry, Weill Cornell Medical College, New York, NY, USA.

L John Horwood (LJ)

Christchurch Health and Development Study, University of Otago, Christchurch, New Zealand.
ORCID: 0000-0003-4881-1956

Craig Johnson (C)

Eating Recovery Center, Denver, CO, USA.

Allan S Kaplan (AS)

Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

Walter H Kaye (WH)

Department of Psychiatry, University of California San Diego, San Diego, CA, USA.

James E Mitchell (JE)

Department of Psychiatry and Behavioral Science, University of North Dakota School of Medicine and Health Sciences, Fargo, ND, USA.

Catherine M Olsen (CM)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
ORCID: 0000-0003-4483-1888

John F Pearson (JF)

Biostatistics and Computational Biology Unit, University of Otago, Christchurch, New Zealand.

Nancy L Pedersen (NL)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Michael Strober (M)

Department of Psychiatry and Biobehavioral Science, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA.
David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Thomas Werge (T)

Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0003-1829-0766

David C Whiteman (DC)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

D Blake Woodside (DB)

Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Centre for Mental Health, University Health Network, Toronto, Ontario, Canada.
Program for Eating Disorders, University Health Network, Toronto, Ontario, Canada.

Garret D Stuber (GD)

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Scott Gordon (S)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
ORCID: 0000-0001-7623-328X

Jakob Grove (J)

Department of Biomedicine, Aarhus University, Aarhus, Denmark.
The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.
Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark.
Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.
ORCID: 0000-0003-2284-5744

Anjali K Henders (AK)

Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.

Anders Juréus (A)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Katherine M Kirk (KM)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
ORCID: 0000-0001-8298-1436

Janne T Larsen (JT)

The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.
National Centre for Register-Based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark.
Centre for Integrated Register-based Research (CIRRAU), Aarhus University, Aarhus, Denmark.

Richard Parker (R)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Liselotte Petersen (L)

The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.
National Centre for Register-Based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark.
Centre for Integrated Register-based Research (CIRRAU), Aarhus University, Aarhus, Denmark.

Jennifer Jordan (J)

Department of Psychological Medicine, University of Otago, Christchurch, New Zealand.
Canterbury District Health Board, Christchurch, New Zealand.

Martin Kennedy (M)

Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
ORCID: 0000-0002-6445-8526

Grant W Montgomery (GW)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.

Tracey D Wade (TD)

School of Psychology, Flinders University, Adelaide, South Australia, Australia.

Andreas Birgegård (A)

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Center for Psychiatry Research, Stockholm Health Care Services, Stockholm City Council, Stockholm, Sweden.

Paul Lichtenstein (P)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0003-3037-5287

Claes Norring (C)

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Center for Psychiatry Research, Stockholm Health Care Services, Stockholm City Council, Stockholm, Sweden.
ORCID: 0000-0002-9459-7279

Mikael Landén (M)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Nicholas G Martin (NG)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
ORCID: 0000-0003-4069-8020

Preben Bo Mortensen (PB)

The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.
National Centre for Register-Based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark.
Centre for Integrated Register-based Research (CIRRAU), Aarhus University, Aarhus, Denmark.

Patrick F Sullivan (PF)

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Gerome Breen (G)

Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
National Institute for Health Research Biomedical Research Centre, King's College London and South London and Maudsley National Health Service Foundation Trust, London, UK.
ORCID: 0000-0003-2053-1792

Cynthia M Bulik (CM)

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. cynthia_bulik@med.unc.edu.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. cynthia_bulik@med.unc.edu.
Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. cynthia_bulik@med.unc.edu.
ORCID: 0000-0001-7772-3264

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questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Genome-wide association study identifies eight...
questionsmedicales.fr › Troubles mentaux › Troubles de l'alimentation › Anorexie mentale › Genome-wide association study identifies eight...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Biométrie › Anthropométrie › Indice de masse corporelle › Genome-wide association study identifies eight...
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questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Genome-wide association study identifies eight...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genome-wide association study identifies eight...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Genome-wide association study identifies eight...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genome-wide association study identifies eight...
questionsmedicales.fr › Troubles mentaux › Genome-wide association study identifies eight...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Genome-wide association study identifies eight...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Genome-wide association study identifies eight...
questionsmedicales.fr › Diagnostic › Pronostic › Genome-wide association study identifies eight...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Locus de caractère quantitatif › Genome-wide association study identifies eight...