Stress, novel sex genes, and epigenetic reprogramming orchestrate socially controlled sex change.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
16
01
2019
accepted:
05
06
2019
entrez:
17
7
2019
pubmed:
17
7
2019
medline:
26
6
2020
Statut:
epublish
Résumé
Bluehead wrasses undergo dramatic, socially cued female-to-male sex change. We apply transcriptomic and methylome approaches in this wild coral reef fish to identify the primary trigger and subsequent molecular cascade of gonadal metamorphosis. Our data suggest that the environmental stimulus is exerted via the stress axis and that repression of the aromatase gene (encoding the enzyme converting androgens to estrogens) triggers a cascaded collapse of feminizing gene expression and identifies notable sex-specific gene neofunctionalization. Furthermore, sex change involves distinct epigenetic reprogramming and an intermediate state with altered epigenetic machinery expression akin to the early developmental cells of mammals. These findings reveal at a molecular level how a normally committed developmental process remains plastic and is reversed to completely alter organ structures.
Identifiants
pubmed: 31309157
doi: 10.1126/sciadv.aaw7006
pii: aaw7006
pmc: PMC6620101
doi:
Substances chimiques
Androgens
0
Estrogens
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eaaw7006Références
Front Neuroendocrinol. 2011 Aug;32(3):320-35
pubmed: 21163292
F1000Res. 2017 Apr 20;6:526
pubmed: 28580133
Nature. 2011 Jul 20;476(7358):101-4
pubmed: 21775990
PLoS One. 2011;6(7):e21800
pubmed: 21789182
Bioinformatics. 2011 Jun 1;27(11):1571-2
pubmed: 21493656
Nat Protoc. 2013 Aug;8(8):1494-512
pubmed: 23845962
BMC Bioinformatics. 2009 Dec 15;10:421
pubmed: 20003500
Sex Dev. 2013;7(1-3):33-45
pubmed: 22846624
Biol Sex Differ. 2010 Nov 04;1(1):3
pubmed: 21208465
Bioinformatics. 2015 Jan 15;31(2):166-9
pubmed: 25260700
Mol Reprod Dev. 2017 Feb;84(2):94-104
pubmed: 28032683
Sex Dev. 2016;10(5-6):223-241
pubmed: 27820936
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Bioinformatics. 2011 Feb 15;27(4):578-9
pubmed: 21149342
Science. 2018 May 11;360(6389):645-648
pubmed: 29748283
Cell. 2009 Dec 11;139(6):1130-42
pubmed: 20005806
Trends Genet. 1996 Sep;12(9):338-9
pubmed: 8855658
Nat Rev Genet. 2017 Nov;18(11):643-658
pubmed: 28804139
PLoS One. 2014 Oct 16;9(10):e110610
pubmed: 25330190
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
Genome Biol. 2014;15(12):550
pubmed: 25516281
Sex Dev. 2009;3(2-3):152-63
pubmed: 19684459
Environ Sci Technol. 2012 Jul 17;46(14):7763-71
pubmed: 22724546
Horm Behav. 2004 May;45(5):345-53
pubmed: 15109909
Cell Rep. 2014 Dec 24;9(6):1990-2000
pubmed: 25497087
Sci Adv. 2017 Jun 14;3(6):e1700731
pubmed: 28630932
Biol Sex Differ. 2015 Nov 25;6:26
pubmed: 26613014
Gen Comp Endocrinol. 2013 Oct 1;192:36-44
pubmed: 23770022
Nature. 2011 Jan 20;469(7330):343-9
pubmed: 21248841
Semin Cell Dev Biol. 2009 May;20(3):264-70
pubmed: 19124081
Front Neurosci. 2013 Nov 08;7:210
pubmed: 24265604
Integr Comp Biol. 2015 Aug;55(2):307-22
pubmed: 25980565
Nat Rev Genet. 2017 Nov;18(11):675-689
pubmed: 28804140
Cell. 2008 Nov 14;135(4):649-61
pubmed: 18992931
Sex Dev. 2016;10(5-6):242-266
pubmed: 27907925
Bioinformatics. 2014 Feb 15;30(4):566-8
pubmed: 24297520
Mol Cell. 2000 Mar;5(3):581-7
pubmed: 10882142
Genome Biol. 2003;4(5):P3
pubmed: 12734009
Dev Dyn. 2013 Apr;242(4):360-70
pubmed: 23335256
Bioinformatics. 2015 Oct 1;31(19):3210-2
pubmed: 26059717
Nucleic Acids Res. 2003 Oct 1;31(19):5654-66
pubmed: 14500829
Mol Genet Genomics. 2014 Dec;289(6):1045-60
pubmed: 25092473
Genome Biol. 2012 Jun 25;13(6):R56
pubmed: 22731987
Cell Stem Cell. 2014 Jun 5;14(6):710-9
pubmed: 24905162
BMC Bioinformatics. 2011 Aug 04;12:323
pubmed: 21816040
Biol Bull. 1991 Oct;181(2):199-204
pubmed: 29304633
Genome Res. 2014 Apr;24(4):604-15
pubmed: 24487721
Bioinformatics. 2014 May 1;30(9):1228-35
pubmed: 24443382
Mol Biol Evol. 2018 Jan 1;35(1):225-241
pubmed: 29136184
Nat Methods. 2012 Mar 04;9(4):357-9
pubmed: 22388286
Front Genet. 2019 Jan 18;9:749
pubmed: 30713551
Bioinformatics. 2005 May 1;21(9):1859-75
pubmed: 15728110
Gen Comp Endocrinol. 1993 Aug;91(2):144-57
pubmed: 8405900
Cell. 2012 Apr 27;149(3):590-604
pubmed: 22541430
BMC Genomics. 2014 Oct 17;15:905
pubmed: 25326170
Sci Rep. 2016 Oct 17;6:35461
pubmed: 27748421
Genome Res. 2002 Apr;12(4):656-64
pubmed: 11932250
Sex Dev. 2013;7(1-3):7-20
pubmed: 22614391
Nat Genet. 2014 Dec;46(12):1350-5
pubmed: 25326702
Integr Comp Biol. 2015 Aug;55(2):294-306
pubmed: 26037297
Nature. 2008 Apr 17;452(7189):877-81
pubmed: 18354397
J Exp Biol. 2015 Jan 15;218(Pt 2):316-25
pubmed: 25524977
J Mol Biol. 1987 Jul 20;196(2):261-82
pubmed: 3656447
Nucleic Acids Res. 2015 Jul 1;43(W1):W589-98
pubmed: 25897122
Cell Rep. 2017 Jan 17;18(3):762-776
pubmed: 28099853
Reproduction. 2017 Dec;154(6):R149-R160
pubmed: 28890443
Methods Mol Biol. 2016;1418:335-51
pubmed: 27008022
PLoS Biol. 2019 Jan 10;17(1):e3000107
pubmed: 30629605
J Steroid Biochem Mol Biol. 2002 Jul;81(3):203-16
pubmed: 12163132
Trends Ecol Evol. 2006 Feb;21(2):89-95
pubmed: 16701480