Semisynthetic Antimycobacterial C-3 Silicate and C-3/C-21 Ester Derivatives of Fusidic Acid: Pharmacological Evaluation and Stability Studies in Liver Microsomes, Rat Plasma, and

Animals Anti-Bacterial Agents / chemical synthesis Bacteriological Techniques CHO Cells Cricetulus Drug Repositioning Esters / chemical synthesis Fusidic Acid / chemistry Microsomes, Liver / chemistry Mycobacterium tuberculosis / drug effects Plasma / chemistry Rats Silicates / chemical synthesis
fusidic acid hydrolysis metabolism prodrug silicate tuberculosis

Journal

ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580

Informations de publication

Date de publication:
13 09 2019
Historique:
pubmed: 17 7 2019
medline: 18 6 2020
entrez: 17 7 2019
Statut: ppublish

Résumé

Fusidic acid (FA), a natural product fusidane triterpene-based antibiotic with unique structural features, is active

Identifiants

DOI: 10.1021/acsinfecdis.9b00208 PMID: 31309823
pubmed: 31309823
doi: 10.1021/acsinfecdis.9b00208
doi:

Substances chimiques

Anti-Bacterial Agents 0
Esters 0
Silicates 0
Fusidic Acid 59XE10C19C

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1634-1644

Auteurs

Mathew Njoroge (M)

Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.
ORCID: 0000-0003-1276-2224

Gurminder Kaur (G)

Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.

Marlene Espinoza-Moraga (M)

Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.

Antonina Wasuna (A)

Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.

Godwin Akpeko Dziwornu (GA)

Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.

Ronnett Seldon (R)

Institute of Infectious Disease and Molecular Medicine , University of Cape Town , Rondebosch 7701 , South Africa.
Drug Discovery and Development Centre (H3D) , University of Cape Town , Rondebosch 7701 , South Africa.

Dale Taylor (D)

Drug Discovery and Development Centre (H3D) , University of Cape Town , Rondebosch 7701 , South Africa.

John Okombo (J)

Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.

Digby F Warner (DF)

Institute of Infectious Disease and Molecular Medicine , University of Cape Town , Rondebosch 7701 , South Africa.
SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DST/NRF Centre of Excellence for Biomedical TB Research, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences , University of Cape Town , Rondebosch 7701 , South Africa.
Wellcome Centre for Infectious Diseases Research in Africa , University of Cape Town , Rondebosch 7701 , South Africa.

Kelly Chibale (K)

Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.
Institute of Infectious Disease and Molecular Medicine , University of Cape Town , Rondebosch 7701 , South Africa.
Drug Discovery and Development Centre (H3D) , University of Cape Town , Rondebosch 7701 , South Africa.
South African Medical Research Council Drug Discovery and Development Research Unit , University of Cape Town , Rondebosch 7701 , South Africa.
ORCID: 0000-0002-1327-4727

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Semisynthetic Antimycobacterial C-3 Silicate...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Semisynthetic Antimycobacterial C-3 Silicate...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Techniques microbiologiques › Techniques bactériologiques › Semisynthetic Antimycobacterial C-3 Silicate...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules CHO › Semisynthetic Antimycobacterial C-3 Silicate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Cricetulus › Semisynthetic Antimycobacterial C-3 Silicate...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Repositionnement des médicaments › Semisynthetic Antimycobacterial C-3 Silicate...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Esters › Semisynthetic Antimycobacterial C-3 Silicate...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Acide fusidique › Semisynthetic Antimycobacterial C-3 Silicate...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Microsomes › Microsomes du foie › Semisynthetic Antimycobacterial C-3 Silicate...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Semisynthetic Antimycobacterial C-3 Silicate...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Plasma sanguin › Semisynthetic Antimycobacterial C-3 Silicate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Semisynthetic Antimycobacterial C-3 Silicate...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du silicium › Silice › Acide silicique › Silicates › Semisynthetic Antimycobacterial C-3 Silicate...