Oxidative stress, inflammatory settings, and microRNA regulation in the recurrent implantation failure patients with metabolic syndrome.
Adult
Cytokines
/ blood
Female
Forkhead Transcription Factors
/ genetics
Humans
Infertility, Female
/ blood
Inflammation
/ blood
Metabolic Syndrome
/ blood
MicroRNAs
NF-kappa B
/ genetics
Oxidative Stress
T-Lymphocytes, Regulatory
/ immunology
Th17 Cells
/ immunology
Transcription Factor AP-1
/ genetics
Young Adult
inflammatory factors
metabolic syndrome
microRNA
oxidative stress
oxidative stress markers
recurrent implantation failure
Journal
American journal of reproductive immunology (New York, N.Y. : 1989)
ISSN: 1600-0897
Titre abrégé: Am J Reprod Immunol
Pays: Denmark
ID NLM: 8912860
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
11
04
2019
revised:
26
06
2019
accepted:
10
07
2019
pubmed:
17
7
2019
medline:
23
7
2020
entrez:
17
7
2019
Statut:
ppublish
Résumé
Increased oxidative stress (OS) and inflammatory factors in metabolic syndrome (MS) patients are considered as risk factors for recurrent implantation failure (RIF). The aim of this study was to investigate OS markers, inflammatory factors, related microRNAs (miRNA) expression, and cytokine and transcription factors RNA expression. We evaluated the frequency of helper T (Th) 17 and regulatory T (Treg) cells in recurrent implantation failure (RIF) women with or without MS. miRNA expression, an inflammatory cytokine, and transcription factors were measured by real-time PCR. The level of interleukin (IL)-1β, IL-6, IL-17, tumour necrosis factor-alpha (TNF-alpha) and chemokine (C-C motif) ligand 2 (CCL-2), and C-X-C motif chemokine ligand 8 (CXCL-8) were measured by enzyme-linked immunosorbent assay (ELISA). OS markers were evaluated by spectrophotometric assay. Th17 and Treg cell frequencies were determined by flow cytometry. The expression of AP1, NF-κB, FOXP3, miRNA-21; serum or plasma level of OS markers (ie, nitric oxide, total oxidant status, and myeloperoxidase); serum level of inflammatory factors (ie, IL1-β, IL-6, IL-17, TNF-alpha, CXCL-8, and CCL-2); and frequency of Th17 cells were increased in RIF-MS patients in comparison with RIF women without MS (RIF-NMS) and control group. The expression of miRNA-223 and 146a, antioxidant enzymes, namely superoxide dismutase (SOD) and catalase (CAT), and frequency of Treg also declined in RIF-MS patients. Overall, our findings suggest that MS in RIF patients causes increased inflammatory factors and OS, which in turn leads to implantation failure.
Substances chimiques
Cytokines
0
FOXP3 protein, human
0
Forkhead Transcription Factors
0
MIRN21 microRNA, human
0
MicroRNAs
0
NF-kappa B
0
Transcription Factor AP-1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13170Subventions
Organisme : Stem Cell Research Center at Tabriz University of Medical Sciences, Iran
ID : 59660
Pays : International
Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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