Conversion from Prediabetes to Diabetes in Individuals with Obesity, 5-Years Post-Band, Sleeve, and Gastric Bypass Surgeries.
Adult
Bariatric Surgery
/ methods
Biomarkers
/ blood
Blood Glucose
/ metabolism
Diabetes Mellitus, Type 2
/ blood
Female
Follow-Up Studies
Humans
Logistic Models
Male
Middle Aged
Obesity, Morbid
/ complications
Postoperative Complications
/ blood
Prediabetic State
/ etiology
Risk Factors
Weight Loss
Diabetes
Metabolic surgery
Obesity
Pre-diabetes
Journal
Obesity surgery
ISSN: 1708-0428
Titre abrégé: Obes Surg
Pays: United States
ID NLM: 9106714
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
pubmed:
18
7
2019
medline:
6
6
2020
entrez:
18
7
2019
Statut:
ppublish
Résumé
Identifying risk factors for conversion to diabetes among individuals with obesity and prediabetes is important for preventing diabetes. We assessed conversion rates to diabetes 5 years after three types of metabolic surgery and examined predictors of diabetes development. We accessed data of individuals with prediabetes, defined as fasting glucose (FG) 100-125 mg/dL (5.6-6.9 mmol/L) or HbA1c 5.7-6.4% at baseline (preoperatively), who underwent metabolic surgeries in Clalit Health Services during 2002-2011. Of 1,756 individuals with prediabetes, 819 underwent gastric banding (GB), 845 sleeve gastrectomy (SG), and 92 Roux-en-Y gastric bypass (RYGB). Mean age was 41.6 years and 73.5% were women. Five years post-surgery, 177 (10.1%) had developed diabetes. Conversion rates by type of surgery were 14.4%, 6.3%, and 6.5% for GB, SG, and RYGB, respectively (p < 0.001). Conversion was more rapid following GB than SG or RYGB (χ Our findings emphasize the importance of preoperative glycemic control and weight loss during the first year postoperatively, for the long-term prevention of diabetes in patients with prediabetes undergoing metabolic surgery.
Sections du résumé
BACKGROUND
Identifying risk factors for conversion to diabetes among individuals with obesity and prediabetes is important for preventing diabetes.
PURPOSE
We assessed conversion rates to diabetes 5 years after three types of metabolic surgery and examined predictors of diabetes development.
METHODS
We accessed data of individuals with prediabetes, defined as fasting glucose (FG) 100-125 mg/dL (5.6-6.9 mmol/L) or HbA1c 5.7-6.4% at baseline (preoperatively), who underwent metabolic surgeries in Clalit Health Services during 2002-2011.
RESULTS
Of 1,756 individuals with prediabetes, 819 underwent gastric banding (GB), 845 sleeve gastrectomy (SG), and 92 Roux-en-Y gastric bypass (RYGB). Mean age was 41.6 years and 73.5% were women. Five years post-surgery, 177 (10.1%) had developed diabetes. Conversion rates by type of surgery were 14.4%, 6.3%, and 6.5% for GB, SG, and RYGB, respectively (p < 0.001). Conversion was more rapid following GB than SG or RYGB (χ
CONCLUSIONS
Our findings emphasize the importance of preoperative glycemic control and weight loss during the first year postoperatively, for the long-term prevention of diabetes in patients with prediabetes undergoing metabolic surgery.
Identifiants
pubmed: 31313239
doi: 10.1007/s11695-019-04090-1
pii: 10.1007/s11695-019-04090-1
doi:
Substances chimiques
Biomarkers
0
Blood Glucose
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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