Generation and characterization of Lhx4

Animals Gene Knock-In Techniques Genes, Reporter Integrases / genetics LIM-Homeodomain Proteins / genetics Luminescent Proteins / genetics Mice Mice, Inbred C57BL Mice, Knockout Mutagenesis, Insertional Transcription Factors / genetics Red Fluorescent Protein
LIM-homeodomain homeobox pituitary gland retina spinal cord

Journal

Genesis (New York, N.Y. : 2000)
ISSN: 1526-968X
Titre abrégé: Genesis
Pays: United States
ID NLM: 100931242

Informations de publication

Date de publication:
10 2019
Historique:
received: 02 01 2019
revised: 28 06 2019
accepted: 06 07 2019
pubmed: 18 7 2019
medline: 11 3 2020
entrez: 18 7 2019
Statut: ppublish

Résumé

LHX4 is a LIM-homeodomain transcription factor essential for the development of spinal cord and pituitary gland. Mice with homozygous Lhx4-null mutation suffer early postnatal death from lung defect. In this study, to facilitate the research on Lhx4 function, we designed a targeting construct to generate two novel Lhx4 mouse lines: Lhx4

Identifiants

DOI: 10.1002/dvg.23328 PMID: 31313880 PMC: PMC6995401
pubmed: 31313880
doi: 10.1002/dvg.23328
pmc: PMC6995401
mid: NIHMS1068877
doi:

Substances chimiques

LIM-Homeodomain Proteins 0
Lhx4 protein, mouse 0
Luminescent Proteins 0
Transcription Factors 0
Cre recombinase EC 2.7.7.-
Integrases EC 2.7.7.-

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e23328

Subventions

Organisme : NEI NIH HHS
ID : R01 EY026614
Pays : United States
Organisme : Department of Ophthalmology at the University of Rochester
ID : RO1EY026614
Pays : International

Informations de copyright

© 2019 Wiley Periodicals, Inc.

Références

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Auteurs

Xuhui Dong (X)

College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Department of Ophthalmology and Flaum Eye Institute, University of Rochester, Rochester, New York.
Institute of Life Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China.
ORCID: 0000-0002-2015-6868

Xiaoling Xie (X)

Department of Ophthalmology and Flaum Eye Institute, University of Rochester, Rochester, New York.

Luming Guo (L)

College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Department of Ophthalmology and Flaum Eye Institute, University of Rochester, Rochester, New York.
Institute of Life Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China.

Jiadong Xu (J)

College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Department of Ophthalmology and Flaum Eye Institute, University of Rochester, Rochester, New York.

Mei Xu (M)

Department of Ophthalmology and Flaum Eye Institute, University of Rochester, Rochester, New York.
Institute of Life Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China.

Guoqing Liang (G)

Institute of Life Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China.

Lin Gan (L)

Department of Ophthalmology and Flaum Eye Institute, University of Rochester, Rochester, New York.
ORCID: 0000-0001-5278-4554

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Generation and characterization of Lhx4
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-in de gènes › Generation and characterization of Lhx4
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes rapporteurs › Generation and characterization of Lhx4
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Recombinases › Integrases › Generation and characterization of Lhx4
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines à domaine LIM › Protéines à homéodomaine LIM › Generation and characterization of Lhx4
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines luminescentes › Generation and characterization of Lhx4
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Generation and characterization of Lhx4
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Generation and characterization of Lhx4
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Generation and characterization of Lhx4
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Mutagenèse par insertion › Generation and characterization of Lhx4
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Generation and characterization of Lhx4