Effects of Nitroglycerine on Renal Ischemia-Reperfusion Injury in Adult Male Rats.
Acute Kidney Injury
/ drug therapy
Animals
Antioxidants
/ metabolism
Creatinine
/ blood
Electrolytes
/ blood
Kidney
/ drug effects
Lipid Peroxidation
/ drug effects
Male
Nitroglycerin
/ metabolism
Oxidative Stress
/ drug effects
Potassium
/ blood
Protective Agents
/ pharmacology
Rats
Rats, Wistar
Regional Blood Flow
/ drug effects
Reperfusion Injury
/ blood
Sodium
/ blood
Journal
Drug research
ISSN: 2194-9387
Titre abrégé: Drug Res (Stuttg)
Pays: Germany
ID NLM: 101602406
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
pubmed:
18
7
2019
medline:
11
3
2020
entrez:
18
7
2019
Statut:
ppublish
Résumé
Ischemia-reperfusion (I-R) leads to acute kidney injury (AKI). The present study investigated the effects of nitroglycerine (NG) on improving renal dysfunctions caused by I-R in rats. Twenty-four rats were equally divided into four groups: (1) the control group, (2) the sham group, (3) the I-R group, and (4) NG-treated groups.NG (50 μg/kg) was injected intraperitoneally after induction of IR. I-R was induced through clamping of the bilateral renal artery and vein of both kidneys for 20 min followed by 24 h of reperfusion. NG significantly increased the creatinine clearance levels and renal blood flow rate (which was reduced by I-R). NG also significantly improved serum electrolytes (sodium and potassium) that were disordered by I-R. In addition, NG significantly offset impaired antioxidant defense mechanism and inhibited lipid peroxidation. The results show NG has a protective effect on renal tissue against AKI caused by I-R. These protective effects mediated through antioxidant activity and decrease of lipid peroxidation.
Sections du résumé
BACKGROUND
BACKGROUND
Ischemia-reperfusion (I-R) leads to acute kidney injury (AKI). The present study investigated the effects of nitroglycerine (NG) on improving renal dysfunctions caused by I-R in rats.
METHODOLOGY
METHODS
Twenty-four rats were equally divided into four groups: (1) the control group, (2) the sham group, (3) the I-R group, and (4) NG-treated groups.NG (50 μg/kg) was injected intraperitoneally after induction of IR. I-R was induced through clamping of the bilateral renal artery and vein of both kidneys for 20 min followed by 24 h of reperfusion.
RESULTS
RESULTS
NG significantly increased the creatinine clearance levels and renal blood flow rate (which was reduced by I-R). NG also significantly improved serum electrolytes (sodium and potassium) that were disordered by I-R. In addition, NG significantly offset impaired antioxidant defense mechanism and inhibited lipid peroxidation.
CONCLUSIONS
CONCLUSIONS
The results show NG has a protective effect on renal tissue against AKI caused by I-R. These protective effects mediated through antioxidant activity and decrease of lipid peroxidation.
Substances chimiques
Antioxidants
0
Electrolytes
0
Protective Agents
0
Sodium
9NEZ333N27
Creatinine
AYI8EX34EU
Nitroglycerin
G59M7S0WS3
Potassium
RWP5GA015D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
612-620Informations de copyright
© Georg Thieme Verlag KG Stuttgart · New York.
Déclaration de conflit d'intérêts
Disclosure The authors report no conflicts of interest in this work.