Tumor Genomic Profiling Guides Patients with Metastatic Gastric Cancer to Targeted Treatment: The VIKTORY Umbrella Trial.

Antineoplastic Combined Chemotherapy Protocols / adverse effects Biomarkers, Tumor Biopsy Circulating Tumor DNA Clinical Decision-Making Computational Biology / methods Disease Management Gene Expression Profiling Gene Expression Regulation, Neoplastic / drug effects Genomics / methods Humans Molecular Targeted Therapy Neoplasm Metastasis Neoplasm Staging Prognosis Stomach Neoplasms / drug therapy Treatment Outcome

Journal

Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693

Informations de publication

Date de publication:
10 2019
Historique:
received: 14 04 2019
revised: 02 07 2019
accepted: 12 07 2019
pubmed: 19 7 2019
medline: 13 8 2020
entrez: 19 7 2019
Statut: ppublish

Résumé

The VIKTORY (targeted agent eValuation In gastric cancer basket KORea) trial was designed to classify patients with metastatic gastric cancer based on clinical sequencing and focused on eight different biomarker groups (

Identifiants

DOI: 10.1158/2159-8290.CD-19-0442 PMID: 31315834
pubmed: 31315834
pii: 2159-8290.CD-19-0442
doi: 10.1158/2159-8290.CD-19-0442
doi:

Substances chimiques

Biomarkers, Tumor 0
Circulating Tumor DNA 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1388-1405

Informations de copyright

©2019 American Association for Cancer Research.

Auteurs

Jeeyun Lee (J)

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jyunlee@skku.edu kkmkys@skku.edu wkkang@skku.edu.

Seung Tae Kim (ST)

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
ORCID: 0000-0002-1106-8030

Kyung Kim (K)

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
ORCID: 0000-0002-1106-8030

Hyuk Lee (H)

Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Iwanka Kozarewa (I)

Oncology Translational Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom.

Peter G S Mortimer (PGS)

Clinical, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, United Kingdom.
ORCID: 0000-0003-2900-2336

Justin I Odegaard (JI)

Guardant Health, Redwood, California.
ORCID: 0000-0001-9957-2962

Elizabeth A Harrington (EA)

Oncology Translational Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom.

Juyoung Lee (J)

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Taehyang Lee (T)

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Sung Yong Oh (SY)

Dong-A University School of Medicine, Busan, Korea.

Jung-Hun Kang (JH)

Department of Internal Medicine, College of Medicine, Gyeongsang National University, Jinju, Korea.

Jung Hoon Kim (JH)

Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea.
ORCID: 0000-0002-1106-8030

Youjin Kim (Y)

Division of Hematology-Oncology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
ORCID: 0000-0002-1106-8030

Jun Ho Ji (JH)

Division of Hematology-Oncology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.

Young Saing Kim (YS)

Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Republic of Korea.
ORCID: 0000-0002-1106-8030

Kyoung Eun Lee (KE)

Division of Hematology-Oncology, Department of Internal Medicine, Ewha Womans University, Seoul, Korea.

Jinchul Kim (J)

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Tae Sung Sohn (TS)

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Ji Yeong An (JY)

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Min-Gew Choi (MG)

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Jun Ho Lee (JH)

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Jae Moon Bae (JM)

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Sung Kim (S)

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
ORCID: 0000-0002-1106-8030

Jae J Kim (JJ)

Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
ORCID: 0000-0002-1106-8030

Yang Won Min (YW)

Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Byung-Hoon Min (BH)

Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Nayoung K D Kim (NKD)

Samsung Genome Institute, Seoul, Korea.
Clinical, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, United Kingdom.
ORCID: 0000-0002-1106-8030

Sally Luke (S)

Oncology Translational Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom.

Young Hwa Kim (YH)

Clinical, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, United Kingdom.
ORCID: 0000-0002-1106-8030

Jung Yong Hong (JY)

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Se Hoon Park (SH)

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Joon Oh Park (JO)

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Young Suk Park (YS)

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Ho Yeong Lim (HY)

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

AmirAli Talasaz (A)

Guardant Health, Redwood, California.

Simon J Hollingsworth (SJ)

Oncology Business Unit, AstraZeneca, Cambridge, United Kingdom.

Kyoung-Mee Kim (KM)

Department of Pathology & Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jyunlee@skku.edu kkmkys@skku.edu wkkang@skku.edu.
ORCID: 0000-0002-1162-9205

Won Ki Kang (WK)

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jyunlee@skku.edu kkmkys@skku.edu wkkang@skku.edu.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Association de médicaments › Protocoles de polychimiothérapie antinéoplasique › Tumor Genomic Profiling Guides Patients with...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Tumor Genomic Profiling Guides Patients with...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytodiagnostic › Biopsie › Tumor Genomic Profiling Guides Patients with...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN tumoral › ADN tumoral circulant › Tumor Genomic Profiling Guides Patients with...
questionsmedicales.fr › Diagnostic › Prise de décision clinique › Tumor Genomic Profiling Guides Patients with...
questionsmedicales.fr › Sciences de l'information › Informatique › Biologie informatique › Tumor Genomic Profiling Guides Patients with...
questionsmedicales.fr › Administration des services de santé › Gestion des soins aux patients › Prise en charge de la maladie › Tumor Genomic Profiling Guides Patients with...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Tumor Genomic Profiling Guides Patients with...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Tumor Genomic Profiling Guides Patients with...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Tumor Genomic Profiling Guides Patients with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Tumor Genomic Profiling Guides Patients with...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Thérapie moléculaire ciblée › Tumor Genomic Profiling Guides Patients with...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Métastase tumorale › Tumor Genomic Profiling Guides Patients with...
questionsmedicales.fr › Diagnostic › Pronostic › Stadification tumorale › Tumor Genomic Profiling Guides Patients with...
questionsmedicales.fr › Diagnostic › Pronostic › Tumor Genomic Profiling Guides Patients with...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies de l'estomac › Tumeurs de l'estomac › Tumor Genomic Profiling Guides Patients with...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Tumor Genomic Profiling Guides Patients with...