Differential Dynamics of Regulatory T-Cell and Th17 Cell Balance in Mesenteric Lymph Nodes and Blood following Early Antiretroviral Initiation during Acute Simian Immunodeficiency Virus Infection.
Th17 cells
Tregs
antiretroviral therapy
early antiretroviral therapy
gut mucosal immunity
human immunodeficiency virus
immune dysfunction
mucosal immunity
regulatory T cells
simian immunodeficiency virus
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
01 10 2019
01 10 2019
Historique:
received:
01
03
2019
accepted:
05
07
2019
pubmed:
19
7
2019
medline:
3
6
2020
entrez:
19
7
2019
Statut:
epublish
Résumé
Increased frequencies of immunosuppressive regulatory T cells (Tregs) are associated with gut lymphoid tissue fibrosis and dysfunction which, in turn, contribute to disease progression in chronic simian immunodeficiency virus/human immunodeficiency virus (SIV/HIV) infection. Mesenteric lymph nodes (MLNs), which drain the large and small intestine, are critical sites for the induction and maintenance of gut mucosal immunity. However, the dynamics of Tregs in MLNs are not well understood due to the lack of accessibility to these tissues in HIV-infected individuals. Here, the dynamics of Tregs in blood and MLNs were assessed in SIV-infected rhesus macaques (RMs) following early antiretroviral drug (ARV) initiation. Early ARV initiation reduced T-cell immune activation, as assessed by HLA-DR/CD39 expression, and prevented the depletion of memory CCR6
Identifiants
pubmed: 31315987
pii: JVI.00371-19
doi: 10.1128/JVI.00371-19
pmc: PMC6744245
pii:
doi:
Substances chimiques
Anti-Retroviral Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
ID : HBF-123682
Pays : Canada
Organisme : CIHR
ID : HBF-126786
Pays : Canada
Organisme : CIHR
ID : MOP-133476
Pays : Canada
Organisme : CIHR
ID : MOP142195
Pays : Canada
Organisme : CIHR
ID : HB2-164064
Pays : Canada
Informations de copyright
Copyright © 2019 Yero et al.
Références
J Immunol. 2005 Mar 15;174(6):3143-7
pubmed: 15749840
Cell Death Differ. 2005 Aug;12 Suppl 1:979-90
pubmed: 15818408
J Infect Dis. 2006 Mar 1;193(5):703-12
pubmed: 16453267
Blood. 2006 Nov 1;108(9):3072-8
pubmed: 16728694
Blood. 2006 Dec 1;108(12):3808-17
pubmed: 16902147
J Immunol. 2006 Nov 15;177(10):6685-94
pubmed: 17082581
J Infect Dis. 2007 Feb 15;195(4):551-61
pubmed: 17230415
Cell Death Differ. 2007 Oct;14(10):1747-58
pubmed: 17612589
Purinergic Signal. 2007 Mar;3(1-2):171-80
pubmed: 18404431
AIDS. 2008 Nov 30;22(18):2451-60
pubmed: 19005268
Mucosal Immunol. 2009 Mar;2(2):173-83
pubmed: 19129757
PLoS Pathog. 2009 Feb;5(2):e1000295
pubmed: 19214220
J Immunol. 2010 Jan 15;184(2):984-92
pubmed: 20018630
J Immunol. 2010 Feb 1;184(3):1604-16
pubmed: 20042588
J Infect Dis. 2010 Mar 15;201(6):843-54
pubmed: 20144043
J Immunol. 2010 Apr 1;184(7):3433-41
pubmed: 20181882
PLoS Pathog. 2010 Apr 08;6(4):e1000852
pubmed: 20386714
PLoS Pathog. 2010 Aug 19;6(8):e1001052
pubmed: 20808901
J Virol. 2011 Feb;85(3):1287-97
pubmed: 21047964
PLoS One. 2011 Jan 31;6(1):e15924
pubmed: 21305005
J Clin Invest. 2011 Mar;121(3):998-1008
pubmed: 21393864
J Immunol. 2011 Apr 15;186(8):4618-30
pubmed: 21398606
PLoS Pathog. 2011 Jul;7(7):e1002110
pubmed: 21750674
PLoS One. 2011;6(12):e28118
pubmed: 22162758
PLoS Pathog. 2012 Jan;8(1):e1002437
pubmed: 22241988
PLoS One. 2012;7(3):e34547
pubmed: 22479644
Blood. 2013 Jan 3;121(1):29-37
pubmed: 23043072
Clin Dev Immunol. 2012;2012:908314
pubmed: 23251223
Trends Mol Med. 2013 Jun;19(6):355-67
pubmed: 23601906
PLoS Pathog. 2013;9(4):e1003319
pubmed: 23658513
Clin Immunol. 2013 Aug;148(2):246-53
pubmed: 23773923
J Infect Dis. 2013 Oct 15;208(8):1202-11
pubmed: 23852127
J Immunol. 2013 Sep 1;191(5):2164-73
pubmed: 23894197
J Virol. 2013 Oct;87(19):10843-54
pubmed: 23903844
PLoS One. 2013 Oct 16;8(10):e78146
pubmed: 24147117
PLoS Pathog. 2014 Jan 30;10(1):e1003890
pubmed: 24497828
Lancet. 2014 Jul 19;384(9939):258-71
pubmed: 24907868
Nature. 2014 Aug 7;512(7512):74-7
pubmed: 25042999
J Infect Dis. 2015 Mar 1;211(5):769-79
pubmed: 25281758
J Infect Dis. 2015 Apr 1;211(7):1068-75
pubmed: 25344521
Curr Opin HIV AIDS. 2015 Jan;10(1):35-42
pubmed: 25415420
PLoS Pathog. 2014 Dec 11;10(12):e1004543
pubmed: 25503054
J Infect Dis. 2015 Aug 1;212(3):355-66
pubmed: 25616404
Arthritis Rheumatol. 2015 Jun;67(6):1491-502
pubmed: 25733061
J Virol. 2015 Sep;89(18):9616-30
pubmed: 26178986
PLoS Pathog. 2015 Dec 07;11(12):e1005287
pubmed: 26640894
Mucosal Immunol. 2016 Sep;9(5):1137-50
pubmed: 26883727
JCI Insight. 2016 Jul 7;1(10):null
pubmed: 27446990
J Int AIDS Soc. 2016 Sep 15;19(1):21163
pubmed: 27637172
Immunity. 2016 Sep 20;45(3):656-668
pubmed: 27653601
AIDS. 2017 Jan 2;31(1):35-48
pubmed: 27835617
J Immunol. 2016 Dec 15;197(12):4535-4539
pubmed: 27837106
Mucosal Immunol. 2017 Jul;10(4):1082-1096
pubmed: 28051083
J Immunol. 2017 Mar 15;198(6):2310-2319
pubmed: 28159903
J Infect Dis. 2017 Mar 15;215(6):911-919
pubmed: 28453847
Eur J Immunol. 2017 Nov;47(11):1925-1935
pubmed: 28667761
Immunity. 2017 Oct 17;47(4):776-788.e5
pubmed: 29045906
Mediators Inflamm. 2017;2017:6825493
pubmed: 29209103
BMC Immunol. 2017 Dec 16;18(1):50
pubmed: 29246111
Front Immunol. 2018 Apr 13;9:734
pubmed: 29706961
AIDS Res Hum Retroviruses. 2019 Mar;35(3):295-305
pubmed: 30398361
Mucosal Immunol. 2019 Jul;12(4):1038-1054
pubmed: 31114010
Immunol Rev. 1998 Feb;161:111-8
pubmed: 9553768