Extra-Adrenal Glucocorticoid Synthesis in the Intestinal Mucosa: Between Immune Homeostasis and Immune Escape.
colorectal cancer
glucocorticoids
inflammatory bowel disease
intestinal immune homeostasis
intestinal mucosa
liver receptor homolog-1
tumor necrosis factor
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
15
04
2019
accepted:
07
06
2019
entrez:
19
7
2019
pubmed:
19
7
2019
medline:
21
10
2020
Statut:
epublish
Résumé
Glucocorticoids (GCs) are steroid hormones predominantly produced in the adrenal glands in response to physiological cues and stress. Adrenal GCs mediate potent anti-inflammatory and immunosuppressive functions. Accumulating evidence in the past two decades has demonstrated other extra-adrenal organs and tissues capable of synthesizing GCs. This review discusses the role and regulation of GC synthesis in the intestinal epithelium in the regulation of normal immune homeostasis, inflammatory diseases of the intestinal mucosa, and the development of intestinal tumors.
Identifiants
pubmed: 31316505
doi: 10.3389/fimmu.2019.01438
pmc: PMC6611402
doi:
Substances chimiques
Cytokines
0
Glucocorticoids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1438Références
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