Key Features Relevant to Select Antigens and TCR From the MHC-Mismatched Repertoire to Treat Cancer.
T-cell receptor (TCR)
TCR cell therapy
TCR characterization
TCR identification
adoptive T-cell transfer therapy
peptide-MHC modeling (p-MHC modeling)
target antigen characterization
trimolecular complex (TCR-p-MHC)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
27
11
2018
accepted:
13
06
2019
entrez:
19
7
2019
pubmed:
19
7
2019
medline:
22
10
2020
Statut:
epublish
Résumé
Adoptive transfer of T cells transgenic for tumor-reactive T-cell receptors (TCR) is an attractive immunotherapeutic approach. However, clinical translation is so far limited due to challenges in the identification of suitable target antigens as well as TCRs that are concurrent safe and efficient. Definition of key characteristics relevant for effective and specific tumor rejection is essential to improve current TCR-based adoptive T-cell immunotherapies. We here characterized in-depth two TCRs derived from the human leukocyte antigen (HLA)-mismatched allogeneic repertoire targeting two different myeloperoxidase (MPO)-derived peptides presented by the same HLA-restriction element side by side comprising state of the art biochemical and cellular
Identifiants
pubmed: 31316521
doi: 10.3389/fimmu.2019.01485
pmc: PMC6611213
doi:
Substances chimiques
Cytokines
0
HLA Antigens
0
Peptides
0
Receptors, Antigen, T-Cell
0
Peroxidase
EC 1.11.1.7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1485Références
Immunogenetics. 1999 Nov;50(3-4):213-9
pubmed: 10602881
Acc Chem Res. 2000 Dec;33(12):889-97
pubmed: 11123888
Nat Immunol. 2001 Mar;2(3):229-34
pubmed: 11224522
Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10037-41
pubmed: 11517324
Nat Med. 2002 Jun;8(6):631-7
pubmed: 12042816
Protein Sci. 2003 May;12(5):1007-17
pubmed: 12717023
Proteins. 2004 May 1;55(2):383-94
pubmed: 15048829
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W665-7
pubmed: 15215472
Blood. 2005 Nov 1;106(9):3062-7
pubmed: 16020516
J Immunol. 1992 Aug 1;149(3):972-80
pubmed: 1634779
Clin Immunol. 2006 May;119(2):135-45
pubmed: 16458072
Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W362-5
pubmed: 16845026
Bioinformatics. 2006 Jul 15;22(14):e16-24
pubmed: 16873467
Blood. 2007 Jan 1;109(1):365-73
pubmed: 16931626
Blood. 2007 Jan 1;109(1):235-43
pubmed: 16968899
Eur J Immunol. 2006 Nov;36(11):3052-9
pubmed: 17051621
Blood. 2007 Mar 15;109(6):2331-8
pubmed: 17082316
Nat Protoc. 2006;1(3):1120-32
pubmed: 17406393
Cell. 2007 Apr 6;129(1):135-46
pubmed: 17418792
Protein Sci. 2007 Jul;16(7):1294-307
pubmed: 17567749
Blood. 2007 Oct 15;110(8):2931-9
pubmed: 17626842
Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3825-30
pubmed: 18308940
Bioinformatics. 2008 Jun 1;24(11):1397-8
pubmed: 18413329
Methods Mol Biol. 2007;409:301-8
pubmed: 18450010
Proteins. 2009 Feb 15;74(3):712-26
pubmed: 18704939
J Immunol. 2010 Feb 1;184(3):1617-29
pubmed: 20042572
J Clin Oncol. 2011 Mar 1;29(7):917-24
pubmed: 21282551
N Engl J Med. 2011 Aug 25;365(8):725-33
pubmed: 21830940
Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):881-6
pubmed: 22223661
Nat Med. 2012 Aug;18(8):1254-61
pubmed: 22842478
Nature. 2013 Feb 21;494(7437):361-5
pubmed: 23376950
J Immunother. 2013 Feb;36(2):133-51
pubmed: 23377668
Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6973-8
pubmed: 23576742
Cancer Cell. 2013 Apr 15;23(4):516-26
pubmed: 23597565
Sci Transl Med. 2013 Jul 3;5(192):192ra87
pubmed: 23825303
Sci Transl Med. 2013 Aug 7;5(197):197ra103
pubmed: 23926201
Immunology. 2014 Jan;141(1):18-26
pubmed: 23927693
Leukemia. 2014 Dec;28(12):2355-66
pubmed: 24736212
Retrovirology. 2015 Feb 20;12:20
pubmed: 25808313
Nat Med. 2015 Aug;21(8):914-921
pubmed: 26193344
Bioinformatics. 2016 Feb 15;32(4):511-7
pubmed: 26515819
J Chem Theory Comput. 2015 Aug 11;11(8):3696-713
pubmed: 26574453
J Chem Theory Comput. 2013 Jul 9;9(7):3084-95
pubmed: 26583988
J Chem Theory Comput. 2013 Sep 10;9(9):3878-88
pubmed: 26592383
J Chem Theory Comput. 2012 Sep 11;8(9):3314-21
pubmed: 26605738
Cancer Res. 2016 Jul 15;76(14):4113-23
pubmed: 27354381
Cytometry A. 2016 Sep;89(9):816-25
pubmed: 27564267
Nat Commun. 2016 Nov 21;7:13404
pubmed: 27869121
Blood. 2017 Mar 9;129(10):1284-1295
pubmed: 28053195
Nature. 2017 May 4;545(7652):98-102
pubmed: 28445461
Blood. 2017 Aug 3;130(5):606-618
pubmed: 28637663
Clin Cancer Res. 2017 Oct 15;23(20):6012-6020
pubmed: 28645940
Front Immunol. 2017 Nov 15;8:1564
pubmed: 29187853
J Exp Med. 1994 Oct 1;180(4):1471-83
pubmed: 7523572
Immunogenetics. 1995;41(4):178-228
pubmed: 7890324
J Immunol. 1994 Jan 1;152(1):163-75
pubmed: 8254189
Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4102-7
pubmed: 8633023
J Exp Med. 1996 Apr 1;183(4):1917-21
pubmed: 8666949
J Mol Graph. 1996 Feb;14(1):33-8, 27-8
pubmed: 8744570
J Virol. 1996 Nov;70(11):7569-79
pubmed: 8892876
J Exp Med. 1996 Dec 1;184(6):2279-86
pubmed: 8976183
J Immunol. 1999 Jan 15;162(2):989-94
pubmed: 9916724