Mesangial Cells Exhibit Features of Antigen-Presenting Cells and Activate CD4+ T Cell Responses.
Animals
Antigen Presentation
/ drug effects
Antigen-Presenting Cells
/ drug effects
CD4-Positive T-Lymphocytes
/ immunology
Cells, Cultured
Histocompatibility Antigens Class II
/ immunology
Humans
Interferon-gamma
/ metabolism
Kidney Diseases
/ immunology
Lymphocyte Activation
/ immunology
Mesangial Cells
/ cytology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Th1 Cells
/ immunology
Journal
Journal of immunology research
ISSN: 2314-7156
Titre abrégé: J Immunol Res
Pays: Egypt
ID NLM: 101627166
Informations de publication
Date de publication:
2019
2019
Historique:
received:
06
09
2018
revised:
01
04
2019
accepted:
14
05
2019
entrez:
19
7
2019
pubmed:
19
7
2019
medline:
21
12
2019
Statut:
epublish
Résumé
Mesangial cells play a prominent role in the development of inflammatory diseases and autoimmune disorders of the kidney. Mesangial cells perform the essential functions of helping to ensure that the glomerular structure is stable and regulating capillary flow, and activated mesangial cells acquire proinflammatory activities. We investigated whether activated mesangial cells display immune properties and control the development of T cell immunity. Flow cytometry analysis was used to study the expression of antigen-presenting cell surface markers and costimulatory molecules in mesangial cells. CD4+ T cell activation induced by mesangial cells was detected in terms of T cell proliferation and cytokine production. IFN- Mesangial cells can present antigen and modulate CD4+ T lymphocyte proliferation and differentiation. Interactions between mesangial cells and T cells are essential for sustaining the inflammatory response in a variety of glomerulonephritides. Therefore, mesangial cells might participate in immune function in the kidney.
Sections du résumé
BACKGROUND
BACKGROUND
Mesangial cells play a prominent role in the development of inflammatory diseases and autoimmune disorders of the kidney. Mesangial cells perform the essential functions of helping to ensure that the glomerular structure is stable and regulating capillary flow, and activated mesangial cells acquire proinflammatory activities. We investigated whether activated mesangial cells display immune properties and control the development of T cell immunity.
METHODS
METHODS
Flow cytometry analysis was used to study the expression of antigen-presenting cell surface markers and costimulatory molecules in mesangial cells. CD4+ T cell activation induced by mesangial cells was detected in terms of T cell proliferation and cytokine production.
RESULTS
RESULTS
IFN-
CONCLUSION
CONCLUSIONS
Mesangial cells can present antigen and modulate CD4+ T lymphocyte proliferation and differentiation. Interactions between mesangial cells and T cells are essential for sustaining the inflammatory response in a variety of glomerulonephritides. Therefore, mesangial cells might participate in immune function in the kidney.
Identifiants
pubmed: 31317046
doi: 10.1155/2019/2121849
pmc: PMC6604415
doi:
Substances chimiques
Histocompatibility Antigens Class II
0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2121849Références
Kidney Int. 2000 Jul;58(1):100-14
pubmed: 10886554
J Immunol. 2000 Sep 1;165(5):2458-64
pubmed: 10946271
Nephrol Dial Transplant. 2001 Feb;16(2):269-75
pubmed: 11158399
Immunity. 2001 Jul;15(1):71-82
pubmed: 11485739
Clin Immunol. 2002 Aug;104(2):161-73
pubmed: 12165277
J Exp Med. 2003 Oct 6;198(7):1089-102
pubmed: 14517277
J Immunol. 2003 Oct 15;171(8):4187-94
pubmed: 14530341
Glia. 2005 Feb;49(3):360-74
pubmed: 15538753
J Am Soc Nephrol. 2005 Jul;16(7):2012-22
pubmed: 15944341
Curr Drug Targets Inflamm Allergy. 2005 Jun;4(3):341-51
pubmed: 16101544
Immunity. 2007 Jan;26(1):117-29
pubmed: 17239632
Mol Immunol. 2007 Apr;44(11):2923-32
pubmed: 17300840
Kidney Int. 2007 Aug;72(3):319-27
pubmed: 17495863
Kidney Blood Press Res. 2007;30(6):421-9
pubmed: 17975322
J Immunol. 2009 Feb 1;182(3):1548-59
pubmed: 19155503
Int Immunopharmacol. 2009 Jul;9(7-8):894-9
pubmed: 19336263
J Immunol Methods. 2009 Oct 31;350(1-2):29-35
pubmed: 19647746
J Am Soc Nephrol. 2011 Feb;22(2):306-16
pubmed: 21164025
J Am Soc Nephrol. 2011 Jun;22(6):1007-18
pubmed: 21566058
PLoS One. 2011 May 10;6(5):e18553
pubmed: 21572994
Kidney Int. 2011 Dec;80(11):1231-8
pubmed: 21866089
J Cell Biochem. 2012 Jun;113(6):2009-19
pubmed: 22275109
Nephron Exp Nephrol. 2012;121(1-2):e1-9
pubmed: 23095207
Clin Immunol. 2013 Sep;148(3):335-43
pubmed: 23200699
J Nephrol. 2013 May-Jun;26(3):437-49
pubmed: 23475470
J Am Soc Nephrol. 2013 May;24(6):906-16
pubmed: 23539760
N Engl J Med. 2013 Jun 20;368(25):2402-14
pubmed: 23782179
Biochem Biophys Res Commun. 2014 Jan 17;443(3):969-74
pubmed: 24361893
PLoS One. 2014 Jan 27;9(1):e87377
pubmed: 24475282
J Immunol. 2014 Jul 1;193(1):317-26
pubmed: 24850720
J Immunol. 1989 Mar 15;142(6):1887-94
pubmed: 2493501
Nat Rev Nephrol. 2015 Feb;11(2):88-101
pubmed: 25331787
Inflamm Bowel Dis. 2015 Jul;21(7):1491-8
pubmed: 25895109
J Pathol. 2015 Sep;237(1):62-71
pubmed: 25965582
Methods Mol Biol. 2016;1344:183-91
pubmed: 26520124
Trends Mol Med. 2015 Dec;21(12):762-775
pubmed: 26614735
PLoS One. 2016 Mar 31;11(3):e0152886
pubmed: 27031095
J Am Soc Nephrol. 2016 Nov;27(11):3368-3382
pubmed: 27036736
Clin Immunol. 2016 Aug;169:89-97
pubmed: 27373970
J Leukoc Biol. 2017 Mar;101(3):759-773
pubmed: 27765819
Am J Pathol. 2017 Apr;187(4):740-751
pubmed: 28183532
Kidney Int. 1988 Mar;33(3):677-84
pubmed: 2835539
PLoS One. 2017 May 26;12(5):e0178352
pubmed: 28552941
Mol Cell Biochem. 2018 Apr;441(1-2):191-199
pubmed: 28875388
Front Immunol. 2018 Mar 28;9:635
pubmed: 29643856
Cancer Invest. 1985;3(2):145-60
pubmed: 2986796
J Biol Chem. 1995 Jul 21;270(29):17528-34
pubmed: 7615558
Cell Immunol. 1994 May;155(2):493-500
pubmed: 8181079
Kidney Int Suppl. 1993 Jan;39:S65-70
pubmed: 8468928
Kidney Int. 1997 May;51(5):1447-53
pubmed: 9150457
J Immunol. 1998 Mar 1;160(5):2139-44
pubmed: 9498751