Mechanism of Single-Stranded DNA Activation of Recombinase Intein Splicing.
Journal
Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623
Informations de publication
Date de publication:
06 08 2019
06 08 2019
Historique:
pubmed:
19
7
2019
medline:
17
6
2020
entrez:
19
7
2019
Statut:
ppublish
Résumé
Inteins, or intervening proteins, are mobile genetic elements translated within host polypeptides and removed through protein splicing. This self-catalyzed process breaks two peptide bonds and rejoins the flanking sequences, called N- and C-exteins, with the intein scarlessly escaping the host protein. As these elements have traditionally been viewed as purely selfish genetic elements, recent work has demonstrated that the conditional protein splicing (CPS) of several naturally occurring inteins can be regulated by a variety of environmental cues relevant to the survival of the host organism or crucial to the invading protein function. The RadA recombinase from the archaeon
Identifiants
pubmed: 31318538
doi: 10.1021/acs.biochem.9b00506
pmc: PMC8409432
mid: NIHMS1734158
doi:
Substances chimiques
DNA, Single-Stranded
0
Recombinases
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3335-3339Subventions
Organisme : NIGMS NIH HHS
ID : F32 GM121000
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM039422
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM044844
Pays : United States
Organisme : NIGMS NIH HHS
ID : R37 GM039422
Pays : United States
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