Bio-inspired nanocomposite by layer-by-layer coating of chitosan/hyaluronic acid multilayers on a hard nanocellulose-hydroxyapatite matrix.
CNCs/HAP matrix
Chitosan
Hyaluronic acid
LBL assembly
Journal
Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156
Informations de publication
Date de publication:
15 Oct 2019
15 Oct 2019
Historique:
received:
10
04
2019
revised:
04
06
2019
accepted:
26
06
2019
entrez:
20
7
2019
pubmed:
20
7
2019
medline:
18
12
2019
Statut:
ppublish
Résumé
This study proposed a layer-by-layer technique on the hard CNCs/hydroxyapatite (HAP) matrix using biodegradable and biocompatible chitosan and hyaluronic acid (HA). Inspired by the mineralized collagen in human bone, the CNCs/HAP matrix was synthesized by a facile in situ HAP coating on the CNCs fibers. The chemical and crystalline structure of the CNCs/HAP matrix was investigated with FTIR, XRD, HRTEM, and SAED. The surface of the CNCs/HAP matrix was analyzed by AFM which showed a flat structure with a roughness of 23.12 nm, however, the surface roughness increased to 56.09 nm with the assembly of chitosan and HA. After the LBL assembly, the surface hydrophilicity of the CNCs/HAP films was improved. Moreover, the CNCs/HAP matrix showed enhanced mechanical property than pure CNCs matrix. Although there is compromise in the mechanical property after the LBL assembly, it is anticipated its bioaffinity and biocompatibility will increase with the incoporation of chitosan and HA.
Identifiants
pubmed: 31320076
pii: S0144-8617(19)30703-9
doi: 10.1016/j.carbpol.2019.115036
pii:
doi:
Substances chimiques
Biocompatible Materials
0
Cellulose
9004-34-6
Hyaluronic Acid
9004-61-9
Chitosan
9012-76-4
Durapatite
91D9GV0Z28
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115036Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.