Impact of AAV2 and Hepatitis B Virus Integration Into Genome on Development of Hepatocellular Carcinoma in Patients with Prior Hepatitis B Virus Infection.
Adult
Aged
Aged, 80 and over
Antibodies, Viral
/ blood
Carcinogenesis
/ genetics
Carcinoma, Hepatocellular
/ blood
DNA, Viral
/ blood
Dependovirus
Female
Gene Expression Regulation, Neoplastic
Genome, Human
/ genetics
Hepatectomy
Hepatitis B Surface Antigens
/ blood
Hepatitis B virus
/ genetics
Hepatitis B, Chronic
/ blood
Humans
Liver
/ pathology
Liver Neoplasms
/ blood
Male
Middle Aged
Oncogenes
/ genetics
Parvovirinae
/ genetics
Virus Integration
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 10 2019
15 10 2019
Historique:
received:
11
12
2018
revised:
29
04
2019
accepted:
11
07
2019
pubmed:
20
7
2019
medline:
22
9
2020
entrez:
20
7
2019
Statut:
ppublish
Résumé
Hepatitis B viral (HBV) DNA is frequently integrated into the genomes of hepatocellular carcinoma (HCC) in patients with chronic HBV infection (chronic HBV, hereafter), whereas the frequency of HBV integration in patients after the disappearance of HBV (prior HBV, hereafter) has yet to be determined. This study aimed to detect integration of HBV and adeno-associated virus type 2 (AAV2) into the human genome as a possible oncogenic event. Virome capture sequencing was performed, using HCC and liver samples obtained from 243 patients, including 73 with prior HBV without hepatitis C viral (HCV) infection and 81 with chronic HBV. Clonal HBV integration events were identified in 11 (15.0%) cases of prior HBV without HCV and 61 (75.3%) cases of chronic HBV ( Despite the seroclearance of hepatitis B surface antigen, HBV or AAV2 integration in prior HBV was not rare; therefore, such patients are at risk of developing HCC.
Identifiants
pubmed: 31320595
pii: 1078-0432.CCR-18-4041
doi: 10.1158/1078-0432.CCR-18-4041
doi:
Substances chimiques
Antibodies, Viral
0
DNA, Viral
0
Hepatitis B Surface Antigens
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6217-6227Informations de copyright
©2019 American Association for Cancer Research.