Protective effects induced by alcoholic Phlomis fruticosa and Phlomis herba-venti extracts in isolated rat colon: Focus on antioxidant, anti-inflammatory, and antimicrobial activities in vitro.
Phlomis
antimicrobial activity
inflammation
oxidative stress
ulcerative colitis
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
01
03
2019
revised:
05
06
2019
accepted:
10
06
2019
pubmed:
20
7
2019
medline:
18
12
2019
entrez:
20
7
2019
Statut:
ppublish
Résumé
Phlomis fruticosa L. and P. herba-venti are species belonging to the Lamiaceae family, which have been traditionally used to prepare tonic and digestive drinks. Multiple studies also demonstrated the inhibitory effects of P. fruticosa extracts and essential oil against oxidative/proinflammatory pathways and bacterial strains deeply involved in ulcerative colitis. Considering these findings, the present study evaluated the effects of alcoholic P. fruticosa and P. herba-venti leaf extracts in isolated rat colon challenged with Escherichia coli lipopolysaccharide (LPS), an ex vivo experimental paradigm of ulcerative colitis. In this context, we assayed colon levels of pro-oxidant and proinflammatory biomarkers, including nitrites, malondialdehyde (MDA), lactate dehydrogenase (LDH), and serotonin (5-HT). Additionally, the extracts have been tested in order to evaluate possible inhibitory effects on specific bacterial and fungal strains involved in ulcerative colitis. Alcoholic P. fruticosa and P. herba-venti extracts were able to blunt LPS-induced nitrite, MDA, 5-HT, and LDH levels in isolated rat colon. The same extracts also inhibited the growth of Pseudomonas aeruginosa, E. coli, Staphylococcus aureus, Candida albicans and Candida tropicalis. In conclusion, our findings show a potential role exerted by alcoholic P. fruticosa and P. herba-venti in managing the clinical symptoms related to ulcerative colitis.
Substances chimiques
Anti-Infective Agents
0
Anti-Inflammatory Agents
0
Antioxidants
0
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2387-2400Subventions
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : FAR 2014
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : FAR 2016
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : FAR 2018
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : FAR 2017
Informations de copyright
© 2019 John Wiley & Sons, Ltd.
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