Telomerase activation in small intestinal neuroendocrine tumours is associated with aberrant
DNA methylation
SI-NET
TERT
Telomere
telomerase
Journal
Epigenetics
ISSN: 1559-2308
Titre abrégé: Epigenetics
Pays: United States
ID NLM: 101265293
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
pubmed:
20
7
2019
medline:
10
6
2020
entrez:
20
7
2019
Statut:
ppublish
Résumé
Telomere maintenance is a critical requirement for enabling replicative immortality and tumour development. Here, telomerase expression and activity, telomere length (TL) and potential regulatory factors that can underlie telomerase machinery alterations in small intestinal neuroendocrine tumours (SI-NETs) were analyzed. Telomerase activity assessed by TRAP assay was increased in SI-NETs compared to normal ileum (
Identifiants
pubmed: 31322481
doi: 10.1080/15592294.2019.1634987
pmc: PMC6791720
doi:
Substances chimiques
TERT protein, human
EC 2.7.7.49
Telomerase
EC 2.7.7.49
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1224-1233Références
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