TOMM40 '523 Associations with Baseline and Longitudinal Cognition in APOE ɛ3 Homozygotes.
Aged
Aged, 80 and over
Alzheimer Disease
/ diagnosis
Apolipoprotein E3
/ genetics
Cohort Studies
Female
Follow-Up Studies
Genetic Association Studies
/ methods
Genetic Variation
/ genetics
Homozygote
Humans
Longitudinal Studies
Male
Membrane Transport Proteins
/ genetics
Mental Status and Dementia Tests
Middle Aged
Mitochondrial Precursor Protein Import Complex Proteins
APOE
TOMM40
cognition
factor analysis
longitudinal
Journal
Journal of Alzheimer's disease : JAD
ISSN: 1875-8908
Titre abrégé: J Alzheimers Dis
Pays: Netherlands
ID NLM: 9814863
Informations de publication
Date de publication:
2019
2019
Historique:
pubmed:
20
7
2019
medline:
10
10
2020
entrez:
20
7
2019
Statut:
ppublish
Résumé
TOMM40 '523 is associated with Alzheimer's disease (AD), but APOE linkage disequilibrium confounds this association. In 170 APOE ɛ3 homozygotes, we evaluated relationships between short and very long TOMM40 alleles and longitudinal declines in three cognitive domains (attention, verbal memory, and executive function). We used factor analysis to create composite scores from 10 individual cognitive tests, and latent growth curve modeling adjusting for clinical status (normal, amnestic mild cognitive impairment, or AD) to summarize initial performance and change over three years. Relative to individuals with two very long TOMM40 alleles, APOEɛ3 homozygotes with one or two short alleles showed lower baseline cognitive performance regardless of clinical status. The number of short or very long TOMM40 alleles was not associated with longitudinal cognitive changes. In APOEɛ3 homozygotes from the University of Kansas Alzheimer's Disease Center cohort, an association between TOMM40 '523 and cognition is consistent with the possibility that TOMM40 influences cognition independent of APOE.
Identifiants
pubmed: 31322569
pii: JAD190293
doi: 10.3233/JAD-190293
pmc: PMC7206989
mid: NIHMS1579870
doi:
Substances chimiques
Apolipoprotein E3
0
Membrane Transport Proteins
0
Mitochondrial Precursor Protein Import Complex Proteins
0
TOMM40 protein, human
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1059-1068Subventions
Organisme : NIA NIH HHS
ID : K99 AG056600
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG035982
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072973
Pays : United States
Organisme : NIA NIH HHS
ID : R00 AG056600
Pays : United States
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