2-Phenyloxazole-4-carboxamide as a Scaffold for Selective Inhibition of Human Monoamine Oxidase B.
2-phenyloxazole-4-carboxamides
competitive inhibitors
cytotoxicity
molecular modeling
monoamine oxidases
Journal
ChemMedChem
ISSN: 1860-7187
Titre abrégé: ChemMedChem
Pays: Germany
ID NLM: 101259013
Informations de publication
Date de publication:
18 09 2019
18 09 2019
Historique:
received:
30
04
2019
revised:
15
07
2019
pubmed:
20
7
2019
medline:
23
9
2020
entrez:
20
7
2019
Statut:
ppublish
Résumé
A series of 2-phenyloxazoles bearing an amide group at position 4 were designed and synthesized for evaluation as potential inhibitors of human recombinant monoamine oxidases (hrMAOs). Results of kinetics experiments demonstrated that all compounds behave as competitive MAO inhibitors, with good selectivity toward the MAO-B isoform. The most potent and selective derivatives are characterized by inhibition constant (K
Identifiants
pubmed: 31322823
doi: 10.1002/cmdc.201900261
doi:
Substances chimiques
Monoamine Oxidase Inhibitors
0
Monoamine Oxidase
EC 1.4.3.4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1641-1652Informations de copyright
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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